Disease relevance of Fever

• SUBJECTS: All fatal unintentional cocaine overdoses from 1990 through 1992 (n = 1382) and all hyperthermia deaths of cocaine users (n = 10) were used to identify a maximum daily temperature threshold above which mortality from cocaine intoxication increased [1].
• Clinicians using the combination of whole-body hyperthermia plus 1,3-bis(2-chloroethyl)-1-nitrosourea should be aware of possible increased marrow toxicity [2].
• We have investigated the effect of 5-hydroxytryptamine (5-HT) on SMT-2A mammary adenocarcinoma blood flow during localized microwave hyperthermia treatment [3].
• Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma [4].
• Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo [5].

Psychiatry related information on Fever

• Triad of hyperthermia, increased REM sleep, and cataplexy during clozapine treatment [6]?
• During social interaction with a female, brain hyperthermia induced by MDMA was significantly potentiated (+89%) [7].
• Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes [8].
• Stereotyped behavior and hyperthermia in dogs: correlation with the levels of amphetamine and p-hydroxyamphetamine in plasma and CSF [9].
• Sixty percent of the variation in DFP-induced hyperthermia, a toxic response seen > 48 h after exposure, can be explained by individual differences in baseline Tc [10].

High impact information on Fever

• Certain side effects were more frequent in the women receiving PGE2 than in those receiving misoprostol: pyrexia (63 percent vs. 11 percent; P < 0.001), uterine pain (67 percent vs. 57 percent, P = 0.58), vomiting (33 percent vs. 4 percent, P = 0.005), and diarrhea (30 percent vs. 4 percent, P = 0.012) [11].
• Sodium nitroprusside in the treatment of extreme pyrexia [12].
• Hyperthermia potentiates doxorubicin-related cardiotoxic effects [13].
• The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction [13].
• In a rabbit model of human tumor necrosis factor (rhuTNF)-induced pyrexia, a murine/human chimeric g4 anti-human TNF-alpha monoclonal antibody (mAb) (cCB0011) showed a dose-dependent inhibition of pyrexia, whereas a g1 isotype variant of the same mAb gave a marked pyrexia that was seen at all doses indicative of an immune complex-mediated response [14].

Chemical compound and disease context of Fever

• Individually, doxorubicin and hyperthermia were tolerated by the patient without incident [13].
• Moreover, indomethacin inhibited hyperthermia produced by intracerebroventricular administration of MDP [15].
• These results indicate that prostaglandin E1 reduces tumor blood flow, elevates tumor temperature during hyperthermia, and retards tumor growth after local heat treatment [16].
• The antitumor efficacy of adding the nitroimidazole radiosensitizing drugs misonidazole and etanidazole or hyperthermia (43 degrees C for 30 min) to Fluosol-DA/carbogen (95% O2/5% CO2) and irradiation was tested in the FSaIIC tumor system [17].
• These findings provide a rational basis for the study in experimental systems of hydralazine-induced enhancement of cell killing by hyperthermia and by agents toxic to hypoxic cells [18].

Biological context of Fever

• Transcriptional activation of heat shock genes is mediated by a presynthesized nuclear protein, the heat shock factor (HSF), which transiently converts from an inactive to an active form in response to hyperthermia [19].
• Epidemiological studies in humans have related teratogenic events to maternal exposures to hyperthermia or ethanol during pregnancy [20].
• Atracurium infusion rates appear to be linear and related to body temperature from 26-42 degrees C. Clinically useful neuromuscular blockade in dogs may be obtained during whole-body hyperthermia by utilizing the 42 degrees C atracurium infusion rate throughout the 38-42 degrees C heating phase [21].
• The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of Bcl-2 and Bax, heat induced a >30-fold increase of tumor necrosis factor (TNF) alpha mRNA expression and a significant increase in TNF-alpha protein secretion [22].
• Pharmacokinetics and toxicity of intraperitoneal cisplatin combined with regional hyperthermia [23].

Anatomical context of Fever

• Differential enhancement of cytotoxicity by combination of the carcinostatic agent benzaldehyde and hyperthermia in simian virus 40-transformed and normal cell lines [24].
• Selective killing of glucose and oxygen-deprived HeLa cells by hyperthermia [25].
• Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR [26].
• Depriving cultured cells of glucose increases glucose-regulated protein synthesis, suppresses heat shock protein synthesis, and increases sensitivity to killing by hyperthermia [27].
• The production of PGE by macrophages after hyperthermia was inhibited either by the addition of 5 X 10(-7) M indomethacin or by the subsequent incubation at 4 degrees C, suggesting that the elevated PGE production by macrophages is mediated through the activation of cyclooxygenase [28].

Gene context of Fever

• Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein [29].
• DTT had no effect on activation of HSF1 by hyperthermia [30].
• In response to hyperthermia, heat shock transcription factor (HSF) activates transcription of a set of genes encoding heat shock proteins (HSPs) [31].
• Because hyperthermia is used for the treatment of colon cancer in combination with chemoradiotherapy, we investigated the influence of hyperthermia on YB-1 activity and the expression of multidrug resistance-related genes [32].
• We found that histone deacetylase 3 (HDAC3) was specifically induced after hyperthermia at 44 degrees C for 30 min at pH 6 [33].

Analytical, diagnostic and therapeutic context of Fever

• For each of the modalities tested, the dose-modifying effect was greater when that therapy preceded rather than followed irradiation (misonidazole 2.7 vs. 1.9, etanidazole 2.4 vs. 1.7, hyperthermia 4.0 vs. 1.7 relative to the effect of radiotherapy alone) [17].
• Local hyperthermia (43 degrees C, 30 min) plus SR-4233 (30 mg/kg) produced a tumor growth delay of 9.1 +/- 2.2 days, whereas SR-4233 alone caused a tumor growth delay of only 1.7 +/- 0.9 days and the hyperthermia, only 1.4 +/- 0.7 days [5].
• A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model [34].
• HCFU (80 mg/kg) and 5-FU (40 mg/kg) (same molarity) were administered orally on the 3rd, 6th, and 9th days after transplantation and simultaneously hyperthermia (43.5 degrees C, 45 min) was induced [35].
• Combined modality therapy with bleomycin, hyperthermia, and radiation [36].

References