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MeSH Review


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Disease relevance of Fever


Psychiatry related information on Fever


High impact information on Fever

  • Certain side effects were more frequent in the women receiving PGE2 than in those receiving misoprostol: pyrexia (63 percent vs. 11 percent; P < 0.001), uterine pain (67 percent vs. 57 percent, P = 0.58), vomiting (33 percent vs. 4 percent, P = 0.005), and diarrhea (30 percent vs. 4 percent, P = 0.012) [11].
  • Sodium nitroprusside in the treatment of extreme pyrexia [12].
  • Hyperthermia potentiates doxorubicin-related cardiotoxic effects [13].
  • The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction [13].
  • In a rabbit model of human tumor necrosis factor (rhuTNF)-induced pyrexia, a murine/human chimeric g4 anti-human TNF-alpha monoclonal antibody (mAb) (cCB0011) showed a dose-dependent inhibition of pyrexia, whereas a g1 isotype variant of the same mAb gave a marked pyrexia that was seen at all doses indicative of an immune complex-mediated response [14].

Chemical compound and disease context of Fever

  • Individually, doxorubicin and hyperthermia were tolerated by the patient without incident [13].
  • Moreover, indomethacin inhibited hyperthermia produced by intracerebroventricular administration of MDP [15].
  • These results indicate that prostaglandin E1 reduces tumor blood flow, elevates tumor temperature during hyperthermia, and retards tumor growth after local heat treatment [16].
  • The antitumor efficacy of adding the nitroimidazole radiosensitizing drugs misonidazole and etanidazole or hyperthermia (43 degrees C for 30 min) to Fluosol-DA/carbogen (95% O2/5% CO2) and irradiation was tested in the FSaIIC tumor system [17].
  • These findings provide a rational basis for the study in experimental systems of hydralazine-induced enhancement of cell killing by hyperthermia and by agents toxic to hypoxic cells [18].

Biological context of Fever


Anatomical context of Fever


Gene context of Fever


Analytical, diagnostic and therapeutic context of Fever


  1. Ambient temperature and mortality from unintentional cocaine overdose. Marzuk, P.M., Tardiff, K., Leon, A.C., Hirsch, C.S., Portera, L., Iqbal, M.I., Nock, M.K., Hartwell, N. JAMA (1998) [Pubmed]
  2. Increased in vitro toxicity to mouse bone marrow with 1,3-bis(2-chloroethyl)-1-nitrosourea and hyperthermia. O'Donnell, J.F., McKoy, W.S., Makuch, R.W., Bull, J.M. Cancer Res. (1979) [Pubmed]
  3. Effect of 5-hydroxytryptamine on tissue blood flow and microwave heating of rat tumors. Shrivastav, S., Joines, W.T., Jirtle, R.L. Cancer Res. (1985) [Pubmed]
  4. Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. Wiedemann, G.J., d'Oleire, F., Knop, E., Eleftheriadis, S., Bucsky, P., Feddersen, S., Klouche, M., Geisler, J., Mentzel, M., Schmucker, P. Cancer Res. (1994) [Pubmed]
  5. Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo. Herman, T.S., Teicher, B.A., Coleman, C.N. Cancer Res. (1990) [Pubmed]
  6. Triad of hyperthermia, increased REM sleep, and cataplexy during clozapine treatment? Blum, A. The Journal of clinical psychiatry. (1990) [Pubmed]
  7. Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions. Brown, P.L., Kiyatkin, E.A. Eur. J. Neurosci. (2004) [Pubmed]
  8. Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. McGregor, I.S., Gurtman, C.G., Morley, K.C., Clemens, K.J., Blokland, A., Li, K.M., Cornish, J.L., Hunt, G.E. Psychopharmacology (Berl.) (2003) [Pubmed]
  9. Stereotyped behavior and hyperthermia in dogs: correlation with the levels of amphetamine and p-hydroxyamphetamine in plasma and CSF. Bareggi, S.R., Gomeni, R., Becker, R.E. Psychopharmacology (Berl.) (1978) [Pubmed]
  10. Factors influencing diisopropyl fluorophosphate-induced hypothermia and hyperthermia in the rat. Gordon, C.J. Neurotoxicology and teratology. (1995) [Pubmed]
  11. A comparison of intravaginal misoprostol with prostaglandin E2 for termination of second-trimester pregnancy. Jain, J.K., Mishell, D.R. N. Engl. J. Med. (1994) [Pubmed]
  12. Sodium nitroprusside in the treatment of extreme pyrexia. Katlic, M.R., Ramos, L.G., Zinner, M.J. N. Engl. J. Med. (1978) [Pubmed]
  13. Hyperthermia potentiates doxorubicin-related cardiotoxic effects. Kim, Y.D., Lees, D.E., Lake, C.R., Whang-Peng, J., Schuette, W., Smith, R., Bull, J. JAMA (1979) [Pubmed]
  14. Differential effect of isotype on efficacy of anti-tumor necrosis factor alpha chimeric antibodies in experimental septic shock. Suitters, A.J., Foulkes, R., Opal, S.M., Palardy, J.E., Emtage, J.S., Rolfe, M., Stephens, S., Morgan, A., Holt, A.R., Chaplin, L.C. J. Exp. Med. (1994) [Pubmed]
  15. Central pyrogenic activity of muramyl dipeptide. Riveau, G., Masek, K., Parant, M., Chedid, L. J. Exp. Med. (1980) [Pubmed]
  16. Increased hyperthermic response with prostaglandin E1 in VX2 liver carcinoma in rabbits. Morita, M., Kuwano, H., Matsuda, H., Mori, M., Sugimachi, K. J. Natl. Cancer Inst. (1991) [Pubmed]
  17. Addition of misonidazole, etanidazole, or hyperthermia to treatment with fluosol-DA/carbogen/radiation. Teicher, B.A., Herman, T.S., Holden, S.A., Jones, S.M. J. Natl. Cancer Inst. (1989) [Pubmed]
  18. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. Okunieff, P., Kallinowski, F., Vaupel, P., Neuringer, L.J. J. Natl. Cancer Inst. (1988) [Pubmed]
  19. A short element required for turning off heat shock transcription factor: evidence that phosphorylation enhances deactivation. Høj, A., Jakobsen, B.K. EMBO J. (1994) [Pubmed]
  20. Mammalian stress proteins HSP70 and HSP28 coinduced by nicotine and either ethanol or heat. Hahn, G.M., Shiu, E.C., Auger, E.A. Mol. Cell. Biol. (1991) [Pubmed]
  21. Determination of continuous atracurium infusion rate in dogs undergoing whole-body hyperthermia. Meyer, R.E., Page, R.L., Thrall, D.E., Dewhirst, M.W., Vose, D.L. Cancer Res. (1986) [Pubmed]
  22. Role of tumor necrosis factor alpha in hyperthermia-induced apoptosis of human leukemia cells. Katschinski, D.M., Robins, H.I., Schad, M., Frede, S., Fandrey, J. Cancer Res. (1999) [Pubmed]
  23. Pharmacokinetics and toxicity of intraperitoneal cisplatin combined with regional hyperthermia. Zakris, E.L., Dewhirst, M.W., Riviere, J.E., Hoopes, P.J., Page, R.L., Oleson, J.R. J. Clin. Oncol. (1987) [Pubmed]
  24. Differential enhancement of cytotoxicity by combination of the carcinostatic agent benzaldehyde and hyperthermia in simian virus 40-transformed and normal cell lines. Ishida, A., Miwa, N., Mizuno, S. Cancer Res. (1983) [Pubmed]
  25. Selective killing of glucose and oxygen-deprived HeLa cells by hyperthermia. Kim, S.H., Kim, J.H., Hahn, E.W., Ensign, N.A. Cancer Res. (1980) [Pubmed]
  26. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. de Vera, M.E., Kim, Y.M., Wong, H.R., Wang, Q., Billiar, T.R., Geller, D.A. Hepatology (1996) [Pubmed]
  27. Nucleoside restoration of heat resistance and suppression of glucose-regulated protein synthesis by glucose-deprived L929 cells. Lanks, K.W., Gao, J.P., Kasambalides, E.J. Cancer Res. (1988) [Pubmed]
  28. Induction of prostaglandin production by hyperthermia in murine peritoneal exudate macrophages. Chen, B.D., Sapareto, S.A., Chou, T.H. Cancer Res. (1987) [Pubmed]
  29. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Ewing, J.F., Maines, M.D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  30. Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. Liu, H., Lightfoot, R., Stevens, J.L. J. Biol. Chem. (1996) [Pubmed]
  31. Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. Yamamoto, A., Mizukami, Y., Sakurai, H. J. Biol. Chem. (2005) [Pubmed]
  32. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. Stein, U., Jürchott, K., Walther, W., Bergmann, S., Schlag, P.M., Royer, H.D. J. Biol. Chem. (2001) [Pubmed]
  33. Inhibition of histone deacetylase 3 stimulates apoptosis induced by heat shock under acidic conditions in human maxillary cancer. Narita, N., Fujieda, S., Tokuriki, M., Takahashi, N., Tsuzuki, H., Ohtsubo, T., Matsumoto, H. Oncogene (2005) [Pubmed]
  34. A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. Needham, D., Anyarambhatla, G., Kong, G., Dewhirst, M.W. Cancer Res. (2000) [Pubmed]
  35. Enhancement of antitumor effects of 1-hexylcarbamoyl-5-fluorouracil combined with hyperthermia on Ehrlich ascites tumor in vivo and Nakahara-Fukuoka sarcoma cell in vitro. Tsumura, M., Yoshiga, K., Takada, K. Cancer Res. (1988) [Pubmed]
  36. Combined modality therapy with bleomycin, hyperthermia, and radiation. Teicher, B.A., Herman, T.S., Holden, S.A. Cancer Res. (1988) [Pubmed]
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