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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Predictive value of obsessive-compulsive personality disorder in antiobsessional pharmacological treatment.

Previous reports have stressed the implication of Personality Disorders as predictors of a poorer treatment outcome in Obsessive-Compulsive Disorder (OCD). The aim of this study was to see whether or not Obsessive-Compulsive Personality Disorder in Obsessive-Compulsive Disorder may be predictive for a poorer outcome to antiobsessive pro-serotonergic pharmacological treatment. For this purpose, 30 OCD patients were divided into two groups according to the presence or absence of Obsessive-Compulsive Personality Disorder. Ten-week standardized treatments with oral SRI drugs were given to look for different outcomes between the two groups in Obsessive-Compulsive symptom severity. At the end of the study we found that the presence of Obsessive-Compulsive Personality Disorder, along with the total number of Personality Disorders, did predict poorer response to pharmacological treatment in OCD.[1]


  1. Predictive value of obsessive-compulsive personality disorder in antiobsessional pharmacological treatment. Cavedini, P., Erzegovesi, S., Ronchi, P., Bellodi, L. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1997) [Pubmed]
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