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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.

The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 ( NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.[1]

References

  1. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Carraway, K.L., Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., Lai, C. Nature (1997) [Pubmed]
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