Gene Review:
Erbb4 - v-erb-a erythroblastic leukemia viral...
Mus musculus
Synonyms:
ErbB4, Her4, Mer4, Proto-oncogene-like protein c-ErbB-4, Receptor tyrosine-protein kinase erbB-4, ...
Johannesson,
Gudmundsdottir,
Lillesaar,
Gudnadottir,
Bjornsson,
Birgisdottir,
Sun,
Nanney,
Brynjolfsson,
Harrison,
Stefansson,
Draper,
Ivarsson,
Sigmundsson,
Wong,
Milan,
McCarthy,
Jonsson,
Chen,
Gonzalo,
Buckley,
Kong,
Zhao,
Fried,
Steinthorsdottir,
Sigfusson,
Hardardottir,
Sigurdsson,
Tidcombe,
Williams,
Tang,
Mutel,
Gulcher,
Sainz,
Ghosh,
Ashworth,
Anderson,
Ingason,
Stefansson,
Warburton,
Frigge,
Shi,
Zhou,
Gurney,
Davidson,
Petursson,
Komurasaki,
Howard,
Concepcion,
Andresson,
Moscatello,
Ingvarsson,
Manolescu,
Jiang,
Montgomery,
Lippman,
Tang,
Bjornsdottir,
Gunnarsdottir,
Gong,
Gong,
Lippman,
Hjaltason,
Brunner,
Lemke,
Harvey,
Risling,
Lai,
Gassmann,
Gudbjartsson,
Panchal,
Chou,
- Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets. Ferretti, E., Di Marcotullio, L., Gessi, M., Mattei, T., Greco, A., Po, A., De Smaele, E., Giangaspero, F., Riccardi, R., Di Rocco, C., Pazzaglia, S., Maroder, M., Alimandi, M., Screpanti, I., Gulino, A. Oncogene (2006)
- Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Tang, C.K., Concepcion, X.Z., Milan, M., Gong, X., Montgomery, E., Lippman, M.E. Cancer Res. (1999)
- Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation. Pinkas-Kramarski, R., Eilam, R., Alroy, I., Levkowitz, G., Lonai, P., Yarden, Y. Oncogene (1997)
- Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury. Erlich, S., Shohami, E., Pinkas-Kramarski, R. Mol. Cell. Neurosci. (2000)
- Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Junttila, T.T., Laato, M., Vahlberg, T., Söderström, K.O., Visakorpi, T., Isola, J., Elenius, K. Clin. Cancer Res. (2003)
- Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R., Lemke, G. Nature (1995)
- gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Ni, C.Y., Murphy, M.P., Golde, T.E., Carpenter, G. Science (2001)
- Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Long, W., Wagner, K.U., Lloyd, K.C., Binart, N., Shillingford, J.M., Hennighausen, L., Jones, F.E. Development (2003)
- Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. de Ledesma, A.M., Desai, A.N., Bolivar, V.J., Symula, D.J., Flaherty, L. Mamm. Genome (2006)
- Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., Nanba, D., Higashiyama, S., Hori, M., Klagsbrun, M., Mekada, E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Neuregulin 1 and susceptibility to schizophrenia. Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T.T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V.G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R.P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A., Lemke, G., Sainz, J., Johannesson, G., Andresson, T., Gudbjartsson, D., Manolescu, A., Frigge, M.L., Gurney, M.E., Kong, A., Gulcher, J.R., Petursson, H., Stefansson, K. Am. J. Hum. Genet. (2002)
- ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4. Wang, L.M., Kuo, A., Alimandi, M., Veri, M.C., Lee, C.C., Kapoor, V., Ellmore, N., Chen, X.H., Pierce, J.H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Zhang, D., Sliwkowski, M.X., Mark, M., Frantz, G., Akita, R., Sun, Y., Hillan, K., Crowley, C., Brush, J., Godowski, P.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Paria, B.C., Elenius, K., Klagsbrun, M., Dey, S.K. Development (1999)
- Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins. Jeschke, M., Wels, W., Dengler, W., Imber, R., Stöcklin, E., Groner, B. Int. J. Cancer (1995)
- Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. Fox, I.J., Kornblum, H.I. J. Neurosci. Res. (2005)
- Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer. Tang, C.K., Gong, X.Q., Moscatello, D.K., Wong, A.J., Lippman, M.E. Cancer Res. (2000)
- Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation. Vecchi, M., Baulida, J., Carpenter, G. J. Biol. Chem. (1996)
- A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. Kainulainen, V., Sundvall, M., Määttä, J.A., Santiestevan, E., Klagsbrun, M., Elenius, K. J. Biol. Chem. (2000)
- A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. Elenius, K., Corfas, G., Paul, S., Choi, C.J., Rio, C., Plowman, G.D., Klagsbrun, M. J. Biol. Chem. (1997)
- ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. Krivosheya, D., Tapia, L., Levinson, J.N., Huang, K., Kang, Y., Hines, R., Ting, A.K., Craig, A.M., Mei, L., Bamji, S.X., El-Husseini, A. J. Biol. Chem. (2008)
- The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development. Murphy, P., Topilko, P., Schneider-Maunoury, S., Seitanidou, T., Baron-Van Evercooren, A., Charnay, P. Development (1996)
- Topical epiregulin enhances repair of murine excisional wounds. Draper, B.K., Komurasaki, T., Davidson, M.K., Nanney, L.B. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2003)
- ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. Jones, F.E., Welte, T., Fu, X.Y., Stern, D.F. J. Cell Biol. (1999)
- Regulation of functional nitric oxide synthase-1 expression in cerebellar granule neurons by heregulin is post-transcriptional, and involves mitogen-activated protein kinase. Krainock, R., Murphy, S. J. Neurochem. (2001)
- Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Howard, B., Panchal, H., McCarthy, A., Ashworth, A. Genes Dev. (2005)
- Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development. Fried, K., Risling, M., Tidcombe, H., Gassmann, M., Lillesaar, C. Dev. Dyn. (2002)
- Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease. Nemo, R., Murcia, N., Dell, K.M. Pediatr. Res. (2005)
- Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse. Bovetti, S., De Marchis, S., Gambarotta, G., Fasolo, A., Perroteau, I., Puche, A.C., Bovolin, P. Brain Res. (2006)
- TACE is required for fetal murine cardiac development and modeling. Shi, W., Chen, H., Sun, J., Buckley, S., Zhao, J., Anderson, K.D., Williams, R.G., Warburton, D. Dev. Biol. (2003)
- Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation. Muraoka-Cook, R.S., Sandahl, M., Hunter, D., Miraglia, L., Earp, H.S. Mol. Endocrinol. (2008)
- Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Jiang, F.X., Harrison, L.C. Differentiation (2005)
- erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation. Lim, H., Das, S.K., Dey, S.K. Dev. Biol. (1998)
- The involvement of ErbB4 with schizophrenia: association and expression studies. Silberberg, G., Darvasi, A., Pinkas-Kramarski, R., Navon, R. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006)
- Exogenous interferon-gamma alters murine inner cell mass and trophoblast development. Effect on the expression of ErbB1, ErbB4 and heparan sulfate proteoglycan (perlecan). Fontana, V., Choren, V., Vauthay, L., Calvo, J.C., Calvo, L., Cameo, M. Reproduction (2004)