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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

5-fluorouracil iontophoretic therapy for Bowen's disease.

BACKGROUND: Topical 5-fluorouracil (5-FU) is an accepted therapy for Bowen's disease. Recurrences with this method have been attributed to deep follicular involvement and poor patient compliance because of the prolonged treatment time required. OBJECTIVE: We sought to determine whether iontophoresis of 5-FU is an effective therapy for Bowen's disease. METHODS: Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks. Local excision was done 3 months after the last treatment. The specimens were step-sectioned and evaluated for any histologic evidence of bowenoid changes. RESULTS: Only 1 of 26 patients showed histologic evidence of Bowen's disease 3 months after treatment. CONCLUSION: 5-FU iontophoresis appears to be a safe, effective, and well-tolerated therapy for Bowen's disease.[1]


  1. 5-fluorouracil iontophoretic therapy for Bowen's disease. Welch, M.L., Grabski, W.J., McCollough, M.L., Skelton, H.G., Smith, K.J., Menon, P.A., Anderson, L.L. J. Am. Acad. Dermatol. (1997) [Pubmed]
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