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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Low cure rate of Helicobacter pylori infection with omeprazole and furazolidone dual therapy for one week.

BACKGROUND: Furazolidone is an inexpensive antibiotic that has considerable anti-Helicobacter pylori activity in vitro. METHODS: Twenty-three patients with culture-proven H. pylori infection were treated for one week with a dual therapy containing omeprazole and furazolidone. RESULTS: Eradication succeeded in 10 of the first 20 evaluable patients (50%; 95% CI: 27.2-72.8%). This percentage was regarded as too low, and the study was terminated. Side-effects were mild. CONCLUSION: With the possible increase in resistance to metronidazole and clarithromycin world-wide, furazolidone may be useful alternative in the treatment of H. pylori infection. Dual therapy for one week, however, is not sufficient.[1]

References

  1. Low cure rate of Helicobacter pylori infection with omeprazole and furazolidone dual therapy for one week. Van Zwet, A.A., Thijs, J.C., van der Wouden, E.J., Kooy, A. Aliment. Pharmacol. Ther. (1997) [Pubmed]
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