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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth.

Unlike normal melanocytes, primary and metastatic human melanomas express high levels of basic fibroblast growth factor ( bFGF) and fibroblast growth factor receptor-1 ( FGFR-1) messenger RNA, and expression of these genes is essential in sustaining the proliferation of malignant melanomas in vitro. To determine whether bFGF and FGFR-1 are also required for tumor formation in these cells, liposome-mediated gene transfer was used to deliver episomal vectors containing antisense-oriented bFGF or FGFR-1 cDNAs into human melanomas, grown as subcutaneous tumors in nude mice. The growth of tumors injected with these constructs was completely arrested or the tumors regressed as a result of blocked intratumoral angiogenesis and subsequent necrosis. Thus, inhibition of bFGF/ FGFR-1-mediated signaling may open a new avenue for the treatment of advanced-stage melanomas.[1]


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