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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Mice, Nude

 
 
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Disease relevance of Mice, Nude

 

Psychiatry related information on Mice, Nude

  • In addition, either the individual or pooled RB+ clones did form malignant tumors in nude mice but usually with a longer latency period and lower frequency [6].
  • Our purpose was to determine the therapeutic efficacy of a selective-spectrum MMPI, ONO-4817 (inhibits MMP-2 and MMP-9 but not MMP-1), against established lung micrometastasis in combination with a cytotoxic anticancer drug, DOC, in a nude mouse model [7].
 

High impact information on Mice, Nude

  • Inactivation of p38 MAPK (the product of Mapk14) in vivo by gene targeting or by PPM1D overexpression expedited tumor formation after injection of mouse embryo fibroblasts (MEFs) expressing E1A+Ras into nude mice [8].
  • Restoration of TSLC1 expression to normal or higher levels suppresses tumor formation by A549 cells in nude mice [9].
  • The defect was not corrected by grafting of Klf4-/- skin onto nude mice [10].
  • Furthermore, normal RLE cells are rapidly transformed when Bog is continuously overexpressed and form hepatoblastoma-like tumours when transplanted into nude mice [11].
  • Recent work has identified a mouse gene (tsg101) whose inactivation in fibroblasts results in cellular transformation and the ability to produce metastatic tumors in nude mice [12].
 

Chemical compound and disease context of Mice, Nude

 

Biological context of Mice, Nude

 

Anatomical context of Mice, Nude

 

Associations of Mice, Nude with chemical compounds

 

Gene context of Mice, Nude

  • Simultaneous adenoviral transfer of p16 and p53 genes leads to inhibition of tumor growth in nude mice [33].
  • One representative human TNF mutant retains its antitumour activity in nude mice carrying tumours derived from human cancers [34].
  • Moreover, mouse asialo-IFN-beta profoundly reduced viremia in vivo in HBV-transfected athymic nude mice, in contrast to conventional IFN-beta, which had no substantial effect [35].
  • Cells expressing mox1 have a transformed appearance, show anchorage-independent growth and produce tumours in athymic mice [36].
  • Transcription of the alpha chain gene was not induced in the NK cell-abundant athymic mice after IL-2 treatment [37].
 

Analytical, diagnostic and therapeutic context of Mice, Nude

References

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