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Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth.

Human erythrocytes release neokyotorphin, the 137-141 fragment of hemoglobin alpha-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1-4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1-4 fragment were shown to stimulate proliferation of L929 tumor cells.[1]

References

  1. Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth. Blishchenko, E.Y., Mernenko, O.A., Yatskin, O.N., Ziganshin, R.H., Philippova, M.M., Karelin, A.A., Ivanov, V.T. FEBS Lett. (1997) [Pubmed]
 
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