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Chemical Compound Review

Neokyotorphin     (2S)-2-[[(2S)-2-[[(2S)-6- amino-2-[[(2S)-2...

Synonyms: neo-kyotorphin, d-Sero-2-nkt, Tskyr peptide, AR-1J3443, LS-177779, ...
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Disease relevance of neo-kyotorphin


High impact information on neo-kyotorphin


Biological context of neo-kyotorphin


Anatomical context of neo-kyotorphin

  • Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin [8].
  • The interaction of neokyotorphin with cell membranes is potentially important to all these multiple biological processes since receptor-mediated processes are thought to be involved in neokyotorphin action [8].
  • Neo-kyotorphin inhibited the Ca2+-dependent and depolarization-evoked release of 3H-GABA, from crude synaptosomes of the lower brain stem of rats [9].
  • When injected into the substantia nigra reticulata, the 10 nmol dose of NKT and d-ser-2-NKT displayed equal seizure-protecting effect, which was higher than that for KT [10].

Associations of neo-kyotorphin with other chemical compounds


Gene context of neo-kyotorphin


Analytical, diagnostic and therapeutic context of neo-kyotorphin


  1. Neo-kyotorphin, an analgesic peptide isolated from human lung carcinoma. Zhu, Y.X., Hsi, K.L., Chen, Z.G., Zhang, H.L., Wu, S.X., Zhang, S.Y., Fang, P.F., Guo, S.Y., Kao, Y.S., Tsou, K. FEBS Lett. (1986) [Pubmed]
  2. Endogenous fragment of hemoglobin, neokyotorphin, as cell growth factor. Blishchenko, E.Y., Kalinina, O.A., Sazonova, O.V., Khaidukov, S.V., Egorova, N.S., Surovoy, A.Y., Philippova, M.M., Vass, A.A., Karelin, A.A., Ivanov, V.T. Peptides (2001) [Pubmed]
  3. State-dependent effects of some neuropeptides and neurotransmitters on neuronal activity of the medial septal area in brain slices of the ground squirrel, Citellus undulatus. Zenchenko, K.I., Kokoz, Y.M., Ivanov, V.T., Ziganshin, R.H., Vinogradova, O.S. Neuroscience (2000) [Pubmed]
  4. Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth. Blishchenko, E.Y., Mernenko, O.A., Yatskin, O.N., Ziganshin, R.H., Philippova, M.M., Karelin, A.A., Ivanov, V.T. FEBS Lett. (1997) [Pubmed]
  5. Hydrolysis of neo-kyotorphin (Thr-Ser-Lys-Tyr-Arg) and [Met]enkephalin-Arg6-Phe7 by angiotensin-converting enzyme from monkey brain. Kase, R., Sekine, R., Katayama, T., Takagi, H., Hazato, T. Biochem. Pharmacol. (1986) [Pubmed]
  6. Inhibitory effects of the analgesic neuropeptides kyotorphin and neo-kyotorphin on enkephalin-degrading enzymes from monkey brain. Hazato, T., Kase, R., Ueda, H., Takagi, H., Katayama, T. Biochem. Int. (1986) [Pubmed]
  7. Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK. Sazonova, O.V., Blishchenko, E.Y., Tolmazova, A.G., Khachin, D.P., Leontiev, K.V., Karelin, A.A., Ivanov, V.T. FEBS J. (2007) [Pubmed]
  8. Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin. Lopes, S.C., Fedorov, A., Castanho, M.A. Chembiochem (2005) [Pubmed]
  9. Non-opioid analgesia of the neuropeptide, neo-kyotorphin and possible mediation by inhibition of GABA release in the mouse brain. Ueda, H., Ge, M., Satoh, M., Takagi, H. Peptides (1987) [Pubmed]
  10. Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy. Godlevsky, L.S., Shandra, A.A., Mikhaleva, I.I., Vastyanov, R.S., Mazarati, A.M. Brain Res. Bull. (1995) [Pubmed]
  11. Isolation from bovine brain of a novel analgesic pentapeptide, neo-kyotorphin, containing the Tyr-Arg (kyotorphin) unit. Fukui, K., Shiomi, H., Takagi, H., Hayashi, K., Kiso, Y., Kitagawa, K. Neuropharmacology (1983) [Pubmed]
  12. Solvent effect on kinetics of appearance of neokyotorphin, VV-haemorphin-4 and a bradykinin-potentiating peptide in the course of peptic hydrolysis of bovine haemoglobin. Lignot, B., Froidevaux, R., Nedjar-Arroume, N., Guillochon, D. Biotechnol. Appl. Biochem. (1999) [Pubmed]
  13. Neokyotorphin formation and quantitative evolution following human hemoglobin hydrolysis with cathepsin D. Zhao, Q., Piot, J.M. Peptides (1998) [Pubmed]
  14. Proliferative activity of neokyotorphin-related hemoglobin fragments in cell cultures. Sazonova, O.V., Blishchenko, E.Y., Kalinina, O.A., Egorova, N.S., Surovoy, A.Y., Philippova, M.M., Karelin, A.A., Ivanov, V.T. Protein Pept. Lett. (2003) [Pubmed]
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