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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Randomised, double-blind, placebo-controlled study of pivagabine in neurasthenia.

One hundred and eighteen patients with neurasthenia, as defined by ICD 10 (International Classification of Diseases), participated in a randomised, double-blind, placebo-controlled trial of pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg). Pivagabine 1800 mg/d was administered orally for four weeks. At the end of the trial, active medication was significantly superior to placebo on the Clinical Global Impression (CGI) improvement of illness scale. In addition, pivagabine treatment reduced the physical and mental fatigability of patients, and increased their sense of well-being.[1]


  1. Randomised, double-blind, placebo-controlled study of pivagabine in neurasthenia. Pizzolato, G., Cagnin, A., Mancia, D., Caffarra, P., Avanzi, S., Copelli, S., Ciappina, C., Lo Presti, F., Spilimbergo, P.G., D'Antonio, E., Di Costanzo, E., Matrango, M., Pastres, P., Urbani, P.P., Signorino, M., Simoncelli, M., Provinciali, L., Regnicolo, L., Albano, C., Roccatagliata, G., Rubino, V., Cultrera, S., Fracassi, M. Arzneimittel-Forschung. (1997) [Pubmed]
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