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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89.

Human N-type Ca2+ channels were rapidly and reversibly inhibited by 5-100 microM BW619C89 (IC50 = 16.4 microM at Vtest = + 10 mV and Vhold = - 90 mV). In the presence of 20 microM BW619C89, activation kinetics were significantly faster. The degree of inhibition observed was affected by both test and holding potential, indicating state-dependent interactions with the N-type Ca2+ channel.[1]

References

  1. Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89. McNaughton, N.C., Leach, M.J., Hainsworth, A.H., Randall, A.D. Neuropharmacology (1997) [Pubmed]
 
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