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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae.

The gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae was cloned and sequenced. The gyrA gene codes for a protein of 822 amino acids homologous to the gyrase A subunit of eubacteria. Translation of the gene in an Escherichia coli expression system revealed a 92-kDa polypeptide. A sequence-directed DNA curvature was identified in the promoter region of gyrA. The bend center was mapped and located between the -35 and -10 regions of the promoter. Primer extension analysis showed that gyrA transcription initiates 6 bp downstream of an extended -10 promoter. The possible implications of the bent DNA region as a regulatory element in the transcription of gyrA are discussed.[1]

References

  1. Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae. Balas, D., Fernández-Moreira, E., De La Campa, A.G. J. Bacteriol. (1998) [Pubmed]
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