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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.

T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent dephosphorylation and inhibited by poorly understood protein kinases. Here, we report the identification of two protein kinases that oppose NF-AT4 nuclear import. Casein kinase Ialpha directly binds and phosphorylates NF-AT4, resulting in the inhibiton of NF-AT4 nuclear translocation. MEKK1 indirectly suppresses NF-AT4 nuclear import by stabilizing the interaction between NF-AT4 and CKIalpha. CKIalpha thus acts to establish an intramolecular masking of the nuclear location signal on NF-AT4, while MEKK1 augments this mechanism, and may further provide a link to signal transduction pathways regulating NF-AT4.[1]


  1. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Zhu, J., Shibasaki, F., Price, R., Guillemot, J.C., Yano, T., Dötsch, V., Wagner, G., Ferrara, P., McKeon, F. Cell (1998) [Pubmed]
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