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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Inhibition of demineralization in vitro around amalgam restorations.

OBJECTIVE: The purpose of this in vitro study was to evaluate some forms of preventing or avoiding demineralization within enamel cavity walls adjacent to amalgam restorations. METHODS AND MATERIALS: Third molar teeth were sectioned to obtain 72 specimens, divided into one control and five experimental groups: amalgam only; varnish plus amalgam; acidulated phosphate fluoride plus amalgam; adhesive amalgam; glass-ionomer cement plus amalgam; control (amalgam only, not subjected to a demineralization challenge). The experimental groups were subjected to PH and thermal cycling and then submitted to enamel hardness determinations. RESULTS: Significant differences between the treatment groups revealed that the bonded amalgam technique offered the best resistance to demineralization. The use of cavity varnish resulted in greater mineral loss than amalgam placed alone. CONCLUSION: The use of an adhesive system, glass-ionomer cement, or acidulated phosphate fluoride under amalgam restorations may interfere with development of secondary caries.[1]


  1. Inhibition of demineralization in vitro around amalgam restorations. Pimenta, L.A., Fontana, U.F., Cury, J.A., Serra, M.C., Elderton, R.J. Quintessence international. (1998) [Pubmed]
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