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MeSH Review

Molar, Third

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Disease relevance of Molar, Third


High impact information on Molar, Third


Chemical compound and disease context of Molar, Third


Biological context of Molar, Third


Anatomical context of Molar, Third


Associations of Molar, Third with chemical compounds


Gene context of Molar, Third

  • A mutation in the MSX1 gene, detected in a single family, resulting in an Arg-->Pro substitution in the homeodomain of the protein product of this gene has previously been associated with the deficiency of second premolars and third molars [30].
  • The second and the third molars appeared to initiate their development by the interaction between the epithelial cells and NCAM-expressing mesenchymal cells [31].
  • Twenty pulps were obtained from freshly extracted human third molars; they were then processed and labeled with I-IGF-1 [32].
  • However, the third molars in the op/op mouse became obscured by the proliferation of neighboring bone trabeculae [33].
  • Is NT-4 a recent addition to the neurotrophic factor repertoire in search of a crucial function, or is it an evolutionary relic, a kind of wisdom tooth of the neurotrophin family [34]?

Analytical, diagnostic and therapeutic context of Molar, Third


  1. The efficacy of locally applied aspirin and acetaminophen in postoperative pain after third molar surgery. Moore, U.J., Seymour, R.A., Rawlins, M.D. Clin. Pharmacol. Ther. (1992) [Pubmed]
  2. Role of TNF-alpha and its receptors in pericoronitis. Beklen, A., Laine, M., Ventä, I., Hyrkäs, T., Konttinen, Y.T. J. Dent. Res. (2005) [Pubmed]
  3. Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report. Barron, R.P., Benoliel, R., Zeltser, R., Eliav, E., Nahlieli, O., Gracely, R.H. Journal of orofacial pain. (2004) [Pubmed]
  4. Fluoride-induced alterations of enamel structure: an experimental study in the miniature pig. Kierdorf, H., Kierdorf, U., Richards, A., Josephsen, K. Anat. Embryol. (2004) [Pubmed]
  5. Expression of IL-8 by cells of the odontoblast layer in vitro. Levin, L.G., Rudd, A., Bletsa, A., Reisner, H. Eur. J. Oral Sci. (1999) [Pubmed]
  6. The mechanism of placebo analgesia. Levine, J.D., Gordon, N.C., Fields, H.L. Lancet (1978) [Pubmed]
  7. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., Feng, J.Q. J. Biol. Chem. (2004) [Pubmed]
  8. Suppression of dental pain by the preoperative administration of flurbiprofen. Dionne, R.A. Am. J. Med. (1986) [Pubmed]
  9. In vivo selectivity of a selective cyclooxygenase 2 inhibitor in the oral surgery model. Khan, A.A., Brahim, J.S., Rowan, J.S., Dionne, R.A. Clin. Pharmacol. Ther. (2002) [Pubmed]
  10. The substance P receptor antagonist CP-99,994 reduces acute postoperative pain. Dionne, R.A., Max, M.B., Gordon, S.M., Parada, S., Sang, C., Gracely, R.H., Sethna, N.F., MacLean, D.B. Clin. Pharmacol. Ther. (1998) [Pubmed]
  11. Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain. Forbes, J.A., Beaver, W.T., Jones, K.F., Edquist, I.A., Gongloff, C.M., Smith, W.K., Smith, F.G., Schwartz, M.K. Clin. Pharmacol. Ther. (1992) [Pubmed]
  12. A placebo-controlled comparative evaluation of diclofenac dispersible versus ibuprofen in postoperative pain after third molar surgery. Bakshi, R., Frenkel, G., Dietlein, G., Meurer-Witt, B., Schneider, B., Sinterhauf, U. Journal of clinical pharmacology. (1994) [Pubmed]
  13. Onset and duration of analgesia for low-dose ketoprofen in the treatment of postoperative dental pain. Sunshine, A., Olson, N.Z., Marrero, I., Tirado, S. Journal of clinical pharmacology. (1998) [Pubmed]
  14. The effect of diclofenac and nefopam on postoperative dental pain. Goucke, C.R., Keaveny, J.P., Kay, B., Healy, T.E., Ryan, M. Anaesthesia. (1990) [Pubmed]
  15. Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain. Forbes, J.A., Jones, K.F., Kehm, C.J., Smith, W.K., Gongloff, C.M., Zeleznock, J.R., Smith, J.W., Beaver, W.T., Kroesen, M. Pharmacotherapy (1990) [Pubmed]
  16. Localization of am3 using EL congenic mouse strains. Shimizu, T., Han, J., Asada, Y., Okamoto, H., Maeda, T. J. Dent. Res. (2005) [Pubmed]
  17. Cloning, characterization and immunolocalization of human ameloblastin. MacDougall, M., Simmons, D., Gu, T.T., Forsman-Semb, K., Mårdh, C.K., Mesbah, M., Forest, N., Krebsbach, P.H., Yamada, Y., Berdal, A. Eur. J. Oral Sci. (2000) [Pubmed]
  18. Human genes for dental anomalies. Kurisu, K., Tabata, M.J. Oral diseases. (1997) [Pubmed]
  19. Effect of preoperative single doses of diclofenac and methylprednisolone on wound healing. Hyrkäs, T. Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi. (1994) [Pubmed]
  20. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. Sammartino, G., Tia, M., Marenzi, G., di Lauro, A.E., D'Agostino, E., Claudio, P.P. J. Oral Maxillofac. Surg. (2005) [Pubmed]
  21. The effects of desensitizing agents on the hydraulic conductance of human dentin in vitro. Greenhill, J.D., Pashley, D.H. J. Dent. Res. (1981) [Pubmed]
  22. A novel organ culture method to study the function of human odontoblasts in vitro: gelatinase expression by odontoblasts is differentially regulated by TGF-beta1. Tjäderhane, L., Salo, T., Larjava, H., Larmas, M., Overall, C.M. J. Dent. Res. (1998) [Pubmed]
  23. Influence of resinous monomers on the differentiation in vitro of human pulp cells into odontoblasts. About, I., Camps, J., Mitsiadis, T.A., Bottero, M.J., Butler, W., Franquin, J.C. J. Biomed. Mater. Res. (2002) [Pubmed]
  24. A two-film versus a four-film bite-wing examination for caries diagnosis in adults. Hintze, H., Wenzel, A. Caries Res. (1999) [Pubmed]
  25. Effect of caffeine on acetaminophen analgesia. Laska, E.M., Sunshine, A., Zighelboim, I., Roure, C., Marrero, I., Wanderling, J., Olson, N. Clin. Pharmacol. Ther. (1983) [Pubmed]
  26. Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery. Hargreaves, K.M., Dionne, R.A., Mueller, G.P., Goldstein, D.S., Dubner, R. Clin. Pharmacol. Ther. (1986) [Pubmed]
  27. Proglumide potentiates morphine analgesia for acute postsurgical pain. Lavigne, G.J., Hargreaves, K.M., Schmidt, E.A., Dionne, R.A. Clin. Pharmacol. Ther. (1989) [Pubmed]
  28. Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain. Olmedo, M.V., Gálvez, R., Vallecillo, M. Pain (2001) [Pubmed]
  29. Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results. Moore, R.A., Edwards, J.E., McQuay, H.J. Pain (2005) [Pubmed]
  30. The novel polymorphic variants within the paired box of the PAX9 gene are associated with selective tooth agenesis. Kobielak, A., Kobielak, K., Wiśniewski, A.S., Mostowska, A., Biedziak, B., Trzeciak, W.H. Folia Histochem. Cytobiol. (2001) [Pubmed]
  31. Expression of the neural cell adhesion molecule during mouse tooth development. Obara, N. Connect. Tissue Res. (2002) [Pubmed]
  32. Expression of insulin-like growth factor-1 receptor in human pulp tissue. Caviedes-Bucheli, J., Muñoz, H.R., Rodríguez, C.E., Lorenzana, T.C., Moreno, G.C., Lombana, N. Journal of endodontics. (2004) [Pubmed]
  33. Lack of the bone remodeling in osteopetrotic (op/op) mice associated with microdontia. Kawata, T., Tokimasa, C., Nowroozi, N., Fujita, T., Kaku, M., Kawasoko, S., Sugiyama, H., Ozawa, S., Zernik, J.H., Tanne, K. J. Craniofac. Genet. Dev. Biol. (1999) [Pubmed]
  34. Neurotrophin-4: the odd one out in the neurotrophin family. Ibáñez, C.F. Neurochem. Res. (1996) [Pubmed]
  35. Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination. McQuay, H.J., Carroll, D., Watts, P.G., Juniper, R.P., Moore, R.A. Pain (1989) [Pubmed]
  36. In vivo and in vitro study of the effects of vitamin A deficiency on rat third molar development. Harris, S.S., Navia, J.M. J. Dent. Res. (1986) [Pubmed]
  37. Genetic mapping of the absence of third molars in EL mice to chromosome 3. Nomura, R., Shimizu, T., Asada, Y., Hirukawa, S., Maeda, T. J. Dent. Res. (2003) [Pubmed]
  38. An immunocytochemical study of the human odontoblast process using antibodies against tubulin, actin, and vimentin. Sigal, M.J., Aubin, J.E., Ten Cate, A.R. J. Dent. Res. (1985) [Pubmed]
  39. A single-dose study of the efficacy and safety of FS 205-397 (250 mg or 500 mg) versus aspirin and placebo in the treatment of postsurgery dental pain. Mehlisch, D.R., Sterling, W.R., Mazza, F.A., Singer, J.M. Journal of clinical pharmacology. (1990) [Pubmed]
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