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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Auxin-induced stress potentiates trans-activation by a conserved plant basic/leucine-zipper factor.

The promoter element activation sequence-1 (as-1) confers tissue-specific and signal-responsive transcription in plants. Hormone and chemical stress cues are thought to activate as-1-dependent transcription through specific basic/leucine-zipper proteins, termed TGA factors, that bind this element. We report here that a highly conserved TGA factor of tobacco, TGA1a, can selectively activate transcription in response to micromolar concentrations of auxin hormones or their analogs. This induction is chemically specific, as a range of other compounds tested at similar concentrations had little or no effect. Auxin was found to augment the trans-activation potential of TGA1a through carboxyl-terminal residues. The amino-terminal domain of TGA1a, by gain-of-function assays, was found to both constitutively activate transcription and maximize the response to auxin. Further evidence indicates that the trans-activation potential of this domain in TGA1a is repressed, under basal conditions, by carboxyl-terminal residues. Because TGA1a and endogenous TGA factors are stimulated by auxin only at concentrations that inhibited cell growth, this response is likely to involve chemical stress.[1]


  1. Auxin-induced stress potentiates trans-activation by a conserved plant basic/leucine-zipper factor. Pascuzzi, P., Hamilton, D., Bodily, K., Arias, J. J. Biol. Chem. (1998) [Pubmed]
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