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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.

A novel 75 kDa membrane protein, TIRC7, is described that exhibits a central role in T cell activation in vitro and in vivo. Modulation of TIRC7- mediated signals with specific anti-TIRC7 antibodies in vitro efficiently prevents human T cell proliferation and IL-2 secretion. Moreover, anti-TIRC7 antibodies specifically inhibit type 1 subset specific IFN-gamma expression but spare the type 2 cytokine IL-4. Diminished proliferation but not IFN-gamma secretion is reversible by exogenous rIL-2. An anti-TIRC7 antibody that cross-reacts with the 75 kDa rat homolog exhibits inhibition of rat alloimmune response in vitro and significantly prolongs kidney allograft survival in vivo. Targeting of TIRC7 may provide a novel therapeutic approach for modulation of the immune response.[1]

References

  1. Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein. Utku, N., Heinemann, T., Tullius, S.G., Bulwin, G.C., Beinke, S., Blumberg, R.S., Beato, F., Randall, J., Kojima, R., Busconi, L., Robertson, E.S., Schülein, R., Volk, H.D., Milford, E.L., Gullans, S.R. Immunity (1998) [Pubmed]
 
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