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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nitrous oxide "analgesia": resemblance to opiate action.

Nitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.[1]


  1. Nitrous oxide "analgesia": resemblance to opiate action. Berkowitz, B.A., Ngai, S.H., Finck, A.D. Science (1976) [Pubmed]
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