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Chemical Compound Review

Laughing gas     nitrous oxide

Synonyms: Lachgas, Stickdioxyd, NITROUS-OXIDE, Factitious air, gaz hilarant, ...
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Disease relevance of nitrous oxide


Psychiatry related information on nitrous oxide


High impact information on nitrous oxide


Chemical compound and disease context of nitrous oxide


Biological context of nitrous oxide


Anatomical context of nitrous oxide


Associations of nitrous oxide with other chemical compounds


Gene context of nitrous oxide


Analytical, diagnostic and therapeutic context of nitrous oxide


  1. Nitrous oxide in myocardial infarction. Eisele, J.H., Reitan, J.A., Miller, R.R. JAMA (1976) [Pubmed]
  2. Nitrous oxide analgesia for refractory pain in the terminally ill. Fosburg, M.T., Crone, R.K. JAMA (1983) [Pubmed]
  3. Purification and characterization of nitrous oxide reductase from Pseudomonas aeruginosa strain P2. SooHoo, C.K., Hollocher, T.C. J. Biol. Chem. (1991) [Pubmed]
  4. Purification and some characteristics of nitrous oxide reductase from Paracoccus denitrificans. Snyder, S.W., Hollocher, T.C. J. Biol. Chem. (1987) [Pubmed]
  5. Purification and some characteristics of a cytochrome c-containing nitrous oxide reductase from Wolinella succinogenes. Teraguchi, S., Hollocher, T.C. J. Biol. Chem. (1989) [Pubmed]
  6. Nitrous oxide and treatment of withdrawal symptoms. Gilmann, M.A., Lichtigfeld, F.J. Lancet (1980) [Pubmed]
  7. Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization. David, H.N., Ansseau, M., Lemaire, M., Abraini, J.H. Biol. Psychiatry (2006) [Pubmed]
  8. Nitrous oxide stimulation of locomotor activity: evidence for an opiate-like behavioral effect. Hynes, M.D., Berkowitz, B.A. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  9. An additive factor analysis of the effect of sub-anaesthetic doses of nitrous oxide on information processing: evidence for an impairment of the motor adjustment stage. Courtière, A., Hardouin, J., Vidal, F., Possamaï, C.A., Hasbroucq, T. Psychopharmacology (Berl.) (2003) [Pubmed]
  10. The effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in healthy volunteers. Janiszewski, D.J., Galinkin, J.L., Klock, P.A., Coalson, D.W., Pardo, H., Zacny, J.P. Anesth. Analg. (1999) [Pubmed]
  11. Nitrous oxide and oxygen in coronary artery disease. Stern, M.S., Shine, K.I. JAMA (1981) [Pubmed]
  12. Nitrous oxide and megaloblastic bone marrow change. Benear, J.B., Eichner, E.R. Lancet (1982) [Pubmed]
  13. Nitrous oxide and vitamin B12. Adornato, B.T. Lancet (1978) [Pubmed]
  14. A novel type of catalytic copper cluster in nitrous oxide reductase. Brown, K., Tegoni, M., Prudêncio, M., Pereira, A.S., Besson, S., Moura, J.J., Moura, I., Cambillau, C. Nat. Struct. Biol. (2000) [Pubmed]
  15. Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Lewis, N.P., Tsao, P.S., Rickenbacher, P.R., Xue, C., Johns, R.A., Haywood, G.A., von der Leyen, H., Trindade, P.T., Cooke, J.P., Hunt, S.A., Billingham, M.E., Valantine, H.A., Fowler, M.B. Circulation (1996) [Pubmed]
  16. Insight into Catalysis of Nitrous Oxide Reductase from High-resolution Structures of Resting and Inhibitor-bound Enzyme from Achromobacter cycloclastes. Paraskevopoulos, K., Antonyuk, S.V., Sawers, R.G., Eady, R.R., Hasnain, S.S. J. Mol. Biol. (2006) [Pubmed]
  17. An Early Example of Evidence-based Medicine: Hypoxemia due to Nitrous Oxide. Cheney, F.W. Anesthesiology (2007) [Pubmed]
  18. Effect of nitrous oxide on cerebral blood velocity while reclining and standing. Mathew, R.J., Wilson, W.H., Humphreys, D., Lowe, J.V. Biol. Psychiatry (1997) [Pubmed]
  19. Left ventricular performance and pulmonary circulation following addition of nitrous oxide to morphine during coronary-artery surgery. Lappas, D.G., Buckley, M.J., Laver, M.B., Daggett, W.M., Lowenstein, E. Anesthesiology (1975) [Pubmed]
  20. Nitrous oxide withdrawal reduces intracranial pressure in the presence of pneumocephalus. Skahen, S., Shapiro, H.M., Drummond, J.C., Todd, M.M., Zelman, V. Anesthesiology (1986) [Pubmed]
  21. Nitrous oxide increases intraocular pressure after intravitreal sulfur hexafluoride injection. Wolf, G.L., Capuano, C., Hartung, J. Anesthesiology (1983) [Pubmed]
  22. Nitrous oxide effects on cerebral evoked potential to pain: partial reversal with a narcotic antagonist. Chapman, C.R., Benedetti, C. Anesthesiology (1979) [Pubmed]
  23. Nitrous oxide impairs the neutrophil oxidative response. Fröhlich, D., Rothe, G., Wittmann, S., Schmitz, G., Schmid, P., Taeger, K., Hobbhahn, J. Anesthesiology (1998) [Pubmed]
  24. Failure of nitrous oxide to inhibit transformation of lymphocytes by phytohemagglutinin. Bruce, D.L. Anesthesiology (1976) [Pubmed]
  25. Nitrous oxide activates GABAergic neurons in the spinal cord in Fischer rats. Hashimoto, T., Maze, M., Ohashi, Y., Fujinaga, M. Anesthesiology (2001) [Pubmed]
  26. Nitrous oxide does not alter infarct volume in rats undergoing reversible middle cerebral artery occlusion. Warner, D.S., Zhou, J.G., Ramani, R., Todd, M.M., McAllister, A. Anesthesiology (1990) [Pubmed]
  27. Nitrous oxide enhances Na+/Ca++ exchange in the neuroblastoma cell line SK-N-SH. Resendes, M.C., Kalogeros, G.C., Dixon, S.J., Philp, R.B. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  28. Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action. Colloc'h, N., Sopkova-de Oliveira Santos, J., Retailleau, P., Vivar??s, D., Bonnet??, F., Langlois d'Estainto, B., Gallois, B., Brisson, A., Risso, J.J., Lemaire, M., Prang??, T., Abraini, J.H. Biophys. J. (2007) [Pubmed]
  29. Re: Nitrous oxide (Entonox) inhalation and tolerance of transrectal ultrasound guided prostate biopsy: a double-blind randomized controlled study. Jones, J.S. J. Urol. (2003) [Pubmed]
  30. Nitrous oxide revisited: evidence for potent antihyperalgesic properties. Richebé, P., Rivat, C., Creton, C., Laulin, J.P., Maurette, P., Lemaire, M., Simonnet, G. Anesthesiology (2005) [Pubmed]
  31. Personnel exposure to waste sevoflurane and nitrous oxide during general anesthesia with cuffed endotracheal tube. Li, S.H., Li, S.N., Shih, H.Y., Yi, H.D., Chiang, C.Y. Acta Anaesthesiol. Sin. (2002) [Pubmed]
  32. Nitrous oxide can enhance the hypnotic effect, but not the suppression of spinal motor neuron excitability by propofol in humans. Kakinohana, M., Miyata, Y., Tomiyama, H., Sugahara, K. Journal of anesthesia. (2006) [Pubmed]
  33. Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Guo, T.Z., Davies, M.F., Kingery, W.S., Patterson, A.J., Limbird, L.E., Maze, M. Anesthesiology (1999) [Pubmed]
  34. Nitrous oxide reductase (nosZ) gene-specific PCR primers for detection of denitrifiers and three nosZ genes from marine sediments. Scala, D.J., Kerkhof, L.J. FEMS Microbiol. Lett. (1998) [Pubmed]
  35. Electron paramagnetic resonance observations on the cytochrome c-containing nitrous oxide reductase from Wolinella succinogenes. Zhang, C.S., Hollocher, T.C., Kolodziej, A.F., Orme-Johnson, W.H. J. Biol. Chem. (1991) [Pubmed]
  36. Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export. Christensen, B., Ueland, P.M. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  37. Nitrous oxide "analgesia": resemblance to opiate action. Berkowitz, B.A., Ngai, S.H., Finck, A.D. Science (1976) [Pubmed]
  38. Chemical conversion of nitrate and nitrite to nitrous oxide for nitrogen and oxygen isotopic analysis in freshwater and seawater. McIlvin, M.R., Altabet, M.A. Anal. Chem. (2005) [Pubmed]
  39. An experimental study to compare methods of eyelash ablation. Bartley, G.B., Bullock, J.D., Olsen, T.G., Lutz, P.D. Ophthalmology (1987) [Pubmed]
  40. Nitrous oxide self-administration by the squirrel monkey. Wood, R.W., Grubman, J., Weiss, B. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
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