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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.

2B4 is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T lymphocyte function. A recombinant protein containing the extracellular region of mouse (m)2B4 attached to avidin-coated fluorescent beads bound to rodent cells, and binding was completely blocked by CD48 monoclonal antibodies (mAbs). Using surface plasmon resonance, we showed that purified soluble mCD48 bound m2B4 with a six- to ninefold higher affinity (Kd approximately 16 microM at 37 degreesC) than its other ligand, CD2. Human CD48 bound human 2B4 with a similar affinity (Kd approximately 8 microM). The finding of an additional ligand for CD48 provides an explanation for distinct functional effects observed on perturbing CD2 and CD48 with mAbs or by genetic manipulation.[1]

References

  1. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. Brown, M.H., Boles, K., van der Merwe, P.A., Kumar, V., Mathew, P.A., Barclay, A.N. J. Exp. Med. (1998) [Pubmed]
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