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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP).

ALDR is one of the four genes encoding an ATP Binding Cassette ( ABC) hemi-transporter of the peroxisomal membrane so far identified in mammalian cells. The best known of these is X-ALD, whose dysfunction has been causally associated with X-linked adrenoleukodystrophy. ALDR and X-ALD protein product are closely related and we show here that this striking conservation is maintained at the genomic level. Although extending to a larger genomic region, the organisation of the mouse ALDR gene mirrors exactly that of X-ALD. This supports further the hypothesis that among the four known peroxisomal ABC hemi-transporters ALDRP is the most likely candidate as a modifier contributing to the phenotypic variability of X- linked adrenoleukodystrophy.[1]

References

  1. Exon organisation of the mouse gene encoding the Adrenoleukodystrophy related protein (ALDRP). Broccardo, C., Troffer-Charlier, N., Savary, S., Mandel, J.L., Chimini, G. Eur. J. Hum. Genet. (1998) [Pubmed]
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