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Gene Review

Abca1  -  ATP-binding cassette, sub-family A (ABC1),...

Mus musculus

Synonyms: ABC-1, ABC1, ATP-binding cassette 1, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ...
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Disease relevance of Abca1


Psychiatry related information on Abca1


High impact information on Abca1


Chemical compound and disease context of Abca1

  • ATP-binding cassette transporter ABCA1 mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins and thus modulates HDL levels and atherogenesis [11].
  • Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure [12].

Biological context of Abca1


Anatomical context of Abca1

  • Astrocytes, the primary producer of CNS apoE, were cultured from Abca1+/+, +/-, and -/- mice, and nascent lipoprotein particles were collected [16].
  • Herein, we have used Abca1-/- mice to ask whether ABCA1 is involved in lipidation of HDL in the central nervous system (CNS) [16].
  • In duodenum, PCN increased Abca1 and Mdr1a mRNA expression in WT mice, but not in PXR-null mice [17].
  • METHODS AND RESULTS: We conducted a series of experiments in macrophages isolated from Abca1-deficient and wild-type mice and compared several of their properties that are thought to be related to the development of atherosclerosis [18].
  • ABCG1-deficient peritoneal macrophages showed induction of several liver X receptor target genes, such as Abca1 and Srebp1c, and a dramatic increase in apolipoprotein E (apoE) protein both in cell media and lysates, without parallel change in apoE mRNA [19].

Associations of Abca1 with chemical compounds


Physical interactions of Abca1


Co-localisations of Abca1

  • We also found that 12-month-old PDAPP Abca1-/- mice had a higher percentage of carbonate-insoluble apoE and that apoE deposits co-localize with amyloid plaques, demonstrating that poorly lipidated apoE co-deposits with insoluble Abeta [6].

Regulatory relationships of Abca1

  • To test this hypothesis, plasma from Abca1(-/-) mice was incubated with CHO cells that are known to express high levels of ABCA1 with the intent of restoring the flux of phospholipid and cholesterol onto apoAI [13].
  • The general ABC transporter inhibitor glibenclamide suppressed both IL-12 p40 and nitric oxide production [24].
  • Furthermore, ABC1 transporters could be a target of therapeutic interest for regulating IL-1beta activity in neuroinflammation disorders [23].
  • OSBP opposes the activity of LXR by negatively regulating ABCA1 activity in the cytoplasm by sterol-binding domain-dependent protein destabilization [25].

Other interactions of Abca1


Analytical, diagnostic and therapeutic context of Abca1


  1. Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells. Panousis, C.G., Zuckerman, S.H. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  2. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Van Eck, M., Singaraja, R.R., Ye, D., Hildebrand, R.B., James, E.R., Hayden, M.R., Van Berkel, T.J. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  3. ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology. Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G.E., Chimini, G. Am. J. Pathol. (2005) [Pubmed]
  4. Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Aiello, R.J., Brees, D., Bourassa, P.A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., Francone, O.L. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  5. Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). Nofer, J.R., Herminghaus, G., Brodde, M., Morgenstern, E., Rust, S., Engel, T., Seedorf, U., Assmann, G., Bluethmann, H., Kehrel, B.E. J. Biol. Chem. (2004) [Pubmed]
  6. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. Wahrle, S.E., Jiang, H., Parsadanian, M., Hartman, R.E., Bales, K.R., Paul, S.M., Holtzman, D.M. J. Biol. Chem. (2005) [Pubmed]
  7. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Oram, J.F., Heinecke, J.W. Physiol. Rev. (2005) [Pubmed]
  8. Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice. Orsó, E., Broccardo, C., Kaminski, W.E., Böttcher, A., Liebisch, G., Drobnik, W., Götz, A., Chambenoit, O., Diederich, W., Langmann, T., Spruss, T., Luciani, M.F., Rothe, G., Lackner, K.J., Chimini, G., Schmitz, G. Nat. Genet. (2000) [Pubmed]
  9. The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder. Dubois-Dalcq, M., Feigenbaum, V., Aubourg, P. Trends Neurosci. (1999) [Pubmed]
  10. Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines. Persiani, D.M., Durdik, J., Selsing, E. J. Exp. Med. (1987) [Pubmed]
  11. Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. Wang, Y., Oram, J.F. J. Biol. Chem. (2005) [Pubmed]
  12. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Komatani, H., Kotani, H., Hara, Y., Nakagawa, R., Matsumoto, M., Arakawa, H., Nishimura, S. Cancer Res. (2001) [Pubmed]
  13. Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Francone, O.L., Subbaiah, P.V., van Tol, A., Royer, L., Haghpassand, M. Biochemistry (2003) [Pubmed]
  14. Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Chuu, C.P., Hiipakka, R.A., Kokontis, J.M., Fukuchi, J., Chen, R.Y., Liao, S. Cancer Res. (2006) [Pubmed]
  15. Liver X Receptor (LXR)-beta Regulation in LXR{alpha}-Deficient Mice: Implications for Therapeutic Targeting. Quinet, E.M., Savio, D.A., Halpern, A.R., Chen, L., Schuster, G.U., Gustafsson, J.A., Basso, M.D., Nambi, P. Mol. Pharmacol. (2006) [Pubmed]
  16. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. Wahrle, S.E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J.D., Kowalewski, T., Holtzman, D.M. J. Biol. Chem. (2004) [Pubmed]
  17. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Cheng, X., Klaassen, C.D. Drug Metab. Dispos. (2006) [Pubmed]
  18. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Francone, O.L., Royer, L., Boucher, G., Haghpassand, M., Freeman, A., Brees, D., Aiello, R.J. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  19. Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with abcg1-/- bone marrow. Ranalletta, M., Wang, N., Han, S., Yvan-Charvet, L., Welch, C., Tall, A.R. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  20. Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL. Groen, A.K., Bloks, V.W., Bandsma, R.H., Ottenhoff, R., Chimini, G., Kuipers, F. J. Clin. Invest. (2001) [Pubmed]
  21. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. Plōsch, T., Kok, T., Bloks, V.W., Smit, M.J., Havinga, R., Chimini, G., Groen, A.K., Kuipers, F. J. Biol. Chem. (2002) [Pubmed]
  22. ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes. Sahoo, D., Trischuk, T.C., Chan, T., Drover, V.A., Ho, S., Chimini, G., Agellon, L.B., Agnihotri, R., Francis, G.A., Lehner, R. J. Lipid Res. (2004) [Pubmed]
  23. ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells. Marty, V., Médina, C., Combe, C., Parnet, P., Amédée, T. Glia (2005) [Pubmed]
  24. Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages. Haskó, G., Deitch, E.A., Németh, Z.H., Kuhel, D.G., Szabó, C. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  25. OSBP negatively regulates ABCA1 protein stability. Bowden, K., Ridgway, N.D. J. Biol. Chem. (2008) [Pubmed]
  26. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mack, J.T., Beljanski, V., Soulika, A.M., Townsend, D.M., Brown, C.B., Davis, W., Tew, K.D. Mol. Cell. Biol. (2007) [Pubmed]
  27. Alpha1-syntrophin modulates turnover of ABCA1. Munehira, Y., Ohnishi, T., Kawamoto, S., Furuya, A., Shitara, K., Imamura, M., Yokota, T., Takeda, S., Amachi, T., Matsuo, M., Kioka, N., Ueda, K. J. Biol. Chem. (2004) [Pubmed]
  28. Regional variations in ABC transporter expression along the mouse intestinal tract. Mutch, D.M., Anderle, P., Fiaux, M., Mansourian, R., Vidal, K., Wahli, W., Williamson, G., Roberts, M.A. Physiol. Genomics (2004) [Pubmed]
  29. The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Chisholm, J.W., Hong, J., Mills, S.A., Lawn, R.M. J. Lipid Res. (2003) [Pubmed]
  30. ApoA-I lipidation in primary mouse hepatocytes. Separate controls for phospholipid and cholesterol transfers. Zheng, H., Kiss, R.S., Franklin, V., Wang, M.D., Haidar, B., Marcel, Y.L. J. Biol. Chem. (2005) [Pubmed]
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