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Chemical Compound Review

Emepride     4-amino-5-bromo-N-(2- diethylaminoethyl)-2...

Synonyms: Artomey, Valopride, Bromoprida, Emoril, Viaben, ...
 
 
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Disease relevance of Viaben

 

Psychiatry related information on Viaben

 

High impact information on Viaben

 

Biological context of Viaben

  • Formulation of bromopride as the solid material in capsules delayed absorption but did not affect the extent of drug bioavailability [9].
  • No evidence for non-linear kinetics was found when bromopride was administered orally in the dose range 10-30 mg: after single oral doses of 10, 20, and 30 mg, peak mean plasma drug concentrations were 20 ng ml-1 +/- 32 per cent CV, 38 ng ml-1 +/- 16 per cent CV, and 64 ng ml-1 +/- 23 per cent CV, respectively [9].
  • Pharmacokinetics and bioavailability of the anti-emetic agent bromopride [9].
 

Associations of Viaben with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Viaben

  • Determination of bromopride in human plasma and urine by high-performance liquid chromatography [12].
  • Withdrawal from long-term bromopride treatment induced not only a significant increase in ambulation and rearing frequencies for male rats observed in the open-field but also an increased sensitivity of both male and female animals to apomorphine [4].
  • Bromopride (20 mg) and the placebo were administered in a 3-min i.v. injection half an hour before chemotherapy and at 3 1/2 and 7 1/2 following chemotherapy [13].

References

  1. Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics. Tonini, M., Cipollina, L., Poluzzi, E., Crema, F., Corazza, G.R., De Ponti, F. Aliment. Pharmacol. Ther. (2004) [Pubmed]
  2. Experimental study on bromopride pharmacology in vivo. antiemetic activity, effects on intestinal transit, on bloating and on gastric ulcers; basal effects on CNS and interferences with the spontaneous motor activity. Giordano, L., Visone, C., Rosatti, R., Di Mezza, G., Montanino, C., Turtur, A., Losanna Cannavacciuolo, G. Agressologie (1980) [Pubmed]
  3. Perinatal bromopride treatment: effects on sexual behavior of male and female rats. Felicio, L.F., Palermo-Neto, J., Nasello, A.G. Behavioral and neural biology. (1989) [Pubmed]
  4. Dopaminergic supersensitivity after long-term bromopride treatment. Felicio, L.F., Nasello, A.G., Palermo-Neto, J. Physiol. Behav. (1987) [Pubmed]
  5. Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study. Nazare, P., Massaroti, P., Duarte, L.F., Campos, D.R., Marchioretto, M.A., Bernasconi, G., Calafatti, S., Barros, F.A., Meurer, E.C., Pedrazzoli, J., Moraes, L.A. Journal of mass spectrometry : JMS. (2005) [Pubmed]
  6. Avoidance behavior, prolactin, HVA and DOPAC in offspring of bromopride-treated rats. Nasello, A.G., Felicio, L.F. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  7. Perinatal bromopride treatment: effects on motor activity and stereotyped behavior of offspring. Felício, L.F., Palermo-Neto, J., Nasello, A.G. Physiol. Behav. (1989) [Pubmed]
  8. A comparison of bromopride and domperidone effects on rat conditioned avoidance and motor activity. Nasello, A.G., Vanzeler, M.L., Felicio, L.F. Pharmacol. Toxicol. (1991) [Pubmed]
  9. Pharmacokinetics and bioavailability of the anti-emetic agent bromopride. Brodie, R.R., Chasseaud, L.F., Darragh, A., Lambe, R.F., Rooney, L., Taylor, T. Biopharmaceutics & drug disposition. (1986) [Pubmed]
  10. Pharmacokinetic study of digoxin-benzamide interaction in the rat. Metivier, B., Servin, A., Renault, H., Jacquot, C. International journal of nuclear medicine and biology. (1984) [Pubmed]
  11. Effect of acute bromopride treatment on rat prolactin levels and sexual behavior. Felício, L.F., Nasello, A.G. Braz. J. Med. Biol. Res. (1989) [Pubmed]
  12. Determination of bromopride in human plasma and urine by high-performance liquid chromatography. Brodie, R.R., Chasseaud, L.F., Rooney, L. J. Chromatogr. (1984) [Pubmed]
  13. Evaluation of the antiemetic activity of bromopride in cancer patients treated with i.v. CMF. Roila, F., Minotti, V., Ballatori, E., Basurto, C., Tonato, M. Tumori. (1985) [Pubmed]
 
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