Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

QWCNQXNAFCBLLV-SJORKVTESA-N (3R,8S)-heptadeca-1,9-dien- 4,6-diyne-3,8-diol

Synonyms:

Shiao, Y.J. et al., Baranska, M. et al., Kim, J.M. et al., Choi, S.Y. et al., Nakano, Y. et al.

Baranska, Schulz,

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High impact information on C08449

Falcarindiol modulated the nuclear translocation of signal transducer and activator of transcription 1 (Stat1) in a time-dependent manner [1].
The inhibitory effect of falcarindiol on iNOS induction was attributable to decrease in the protein content and the mRNA level of iNOS [1].
Falcarindiol abrogated the LPS/IFN-gamma-mediated induction of iNOS by about 80% [1].
Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes [1].
Treatment with 50 microM of falcarindiol for 60 min diminished the LPS/IFN-gamma-mediated activation of IkappaB kinase-alpha (IKK-alpha) and IKK-beta by 28.2 and 29.7%, respectively [1].

Biological context of C08449

The molecular structures of falcarinol, falcarindiol and falcarindiol 3-acetate are similar but their Raman spectra exhibit differences demonstrated by the shift of their -C triple bond C- mode [2].

Anatomical context of C08449

Falcarindiol dose-dependently reduced inducible NO synthase (iNOS)-mediated NO production without cytotoxic effects on LPS-activated BV-2 and microglia [3].

Associations of C08449 with other chemical compounds

The effects of falcarindiol on the expression of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) in rat primary astrocytes were investigated [1].
Panaxynol and falcarindiol were successfully isolated from the root of Heracleum moellendorffii as antiproliferative polyacetylenes [4].

Gene context of C08449

Of the isolated pure compounds, imperatorin and falcarindiol inactivated the GABA-T activities in both time- and concentration-dependent manners [5].

References

Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes. Shiao, Y.J., Lin, Y.L., Sun, Y.H., Chi, C.W., Chen, C.F., Wang, C.N. Br. J. Pharmacol. (2005) [Pubmed]
Spatial tissue distribution of polyacetylenes in carrot root. Baranska, M., Schulz, H. The Analyst. (2005) [Pubmed]
Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. Kim, J.M., Lee, P., Son, D., Kim, H., Kim, S.Y. Neuroreport (2003) [Pubmed]
Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. Nakano, Y., Matsunaga, H., Saita, T., Mori, M., Katano, M., Okabe, H. Biol. Pharm. Bull. (1998) [Pubmed]
In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. Choi, S.Y., Ahn, E.M., Song, M.C., Kim, D.W., Kang, J.H., Kwon, O.S., Kang, T.C., Baek, N.I. Phytotherapy research : PTR. (2005) [Pubmed]

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