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Gene Review:

CEBPD - CCAAT/enhancer binding protein (C/EBP), delta

Homo sapiens

Synonyms: C/EBP delta, C/EBP-delta, CCAAT/enhancer-binding protein delta, CELF, CRP3, ...

Sato, Y. et al., Tanabe, H. et al., Wang, J.M. et al., Kinoshita, S. et al., Ho, T.H. et al., et al.

Angeloni, Lee, Johnson, Teh, Dean, Lerman, Sterneck,

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Disease relevance of CEBPD

The CCAAT/enhancer binding protein delta (C/EBPdelta, CRP3, CELF, NF-IL6beta) regulates gene expression and plays functional roles in many tissues, such as in acute phase response to inflammatory stimuli, adipocyte differentiation, and mammary epithelial cell growth control [1].
Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors [2].
Of the peptides analyzed, only RMAD-4 inhibited HIV infectivity at 150 microg/ml, and Crp3 unexpectedly increased HIV replication [3].

High impact information on CEBPD

The results are consistent with a mechanism for DM pathogenesis in which expanded repeats cause a loss of MBNL and/or gain of CELF activities, leading to misregulation of alternative splicing of specific pre-mRNA targets [4].
Furthermore, NF-IL6 beta shows a synergistic transcriptional effect with NF-IL6 [5].
NF-IL6 beta easily forms a heterodimer with NF-IL6 in vitro and the heterodimeric complex binds to the same DNA sequence as the respective homodimers [5].
The expression of Cebpb, Cebpd and Ccl2 mRNAs in the aortas from fructose-fed rats were significantly elevated, by 330, 300 and 300%, respectively, compared with those of control-fed rats [6].
STAT3-specific genes included the apoptosis regulators CCAAT enhancer binding protein-delta, phosphatidylinositol 3-kinase-regulatory subunits, purine nucleoside phosphorylase, and c-fos [7].

Biological context of CEBPD

C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2 [8].
Therefore, two alpha-defensins, RMAD-4 and Crp3, inhibit or augment HIV replication, respectively, by mechanisms that precede reverse transcription [3].

Anatomical context of CEBPD

The induction Ccl2 mRNA expression in the aortas was significantly correlated with the expression of Cebpb and Cebpd mRNAs in the aortas [6].

Associations of CEBPD with chemical compounds

SM exon splicing can be activated by CELF proteins, which also bind co-operatively to interspersed sites and displace PTB from the pyrimidine tract [9].

Other interactions of CEBPD

Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p [10].

Analytical, diagnostic and therapeutic context of CEBPD

The expression of Ccl2, Cebpb and Cebpd mRNAs was investigated by quantitative RT-PCR [6].

References

Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. Wang, J.M., Tseng, J.T., Chang, W.C. Mol. Biol. Cell (2005) [Pubmed]
Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors. Tang, D., Sivko, G.S., Dewille, J.W. Breast Cancer Res. Treat. (2006) [Pubmed]
Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. Tanabe, H., Ouellette, A.J., Cocco, M.J., Robinson, W.E. J. Virol. (2004) [Pubmed]
Muscleblind proteins regulate alternative splicing. Ho, T.H., Charlet-B, N., Poulos, M.G., Singh, G., Swanson, M.S., Cooper, T.A. EMBO J. (2004) [Pubmed]
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Kinoshita, S., Akira, S., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats. Sato, Y., Nishio, Y., Sekine, O., Kodama, K., Nagai, Y., Nakamura, T., Maegawa, H., Kashiwagi, A. Diabetologia (2007) [Pubmed]
The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Clarkson, R.W., Boland, M.P., Kritikou, E.A., Lee, J.M., Freeman, T.C., Tiffen, P.G., Watson, C.J. Mol. Endocrinol. (2006) [Pubmed]
C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2. Angeloni, D., Lee, J.D., Johnson, B.E., Teh, B.T., Dean, M., Lerman, M.I., Sterneck, E. Mol. Cell. Probes (2001) [Pubmed]
Regulation of alternative splicing by PTB and associated factors. Spellman, R., Rideau, A., Matlin, A., Gooding, C., Robinson, F., McGlincy, N., Grellscheid, S.N., Southby, J., Wollerton, M., Smith, C.W. Biochem. Soc. Trans. (2005) [Pubmed]
Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p. Wood, S., Schertzer, M., Yaremko, M.L. Cytogenet. Cell Genet. (1995) [Pubmed]

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