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ARPP19  -  cAMP-regulated phosphoprotein, 19kDa

Homo sapiens

Synonyms: ARPP-16, ARPP-19, ARPP16, ENSAL, cAMP-regulated phosphoprotein 19
 
 
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Disease relevance of ARPP-19

 

High impact information on ARPP-19

 

Biological context of ARPP-19

 

Anatomical context of ARPP-19

 

Other interactions of ARPP-19

  • The three sequences corresponded to a human gene homologous to the yeast translation initiation factor Sui-1, a cAMP-regulated phosphoprotein, ARPP-16/19, and a novel gene designated O48 [7].
 

Analytical, diagnostic and therapeutic context of ARPP-19

  • We subsequently determined protein levels of ARPP-19 in temporal cortex and cerebellum by immunoblotting and observed significant reduction of ARPP-19 in DS (temporal cortex) and AD (cerebellum) [1].
  • In situ hybridization and Northern blot analysis with the human cDNA probes were used to study the expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human postmortem brain tissue [2].
  • Semiquantitative RT-PCR verified that ARPP-16 is up-regulated in the select line and determined that the relative expression level of ARPP16 mRNA is approximately fourfold higher (P < .01) in the select than in the control animals [5].
  • Of these genes, ARPP-16/19 (cAMP-regulated phosphoprotein 16/19) is selectively enhanced after denervation [6].
  • Sequence analysis indicated that C4-2 has a 94% sequence identity to a family of cAMP-regulated phosphoproteins (ARPP-16/19) in the coding region [8].

References

  1. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. Kim, S.H., Nairn, A.C., Cairns, N., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
  2. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. Brené, S., Lindefors, N., Ehrlich, M., Taubes, T., Horiuchi, A., Kopp, J., Hall, H., Sedvall, G., Greengard, P., Persson, H. J. Neurosci. (1994) [Pubmed]
  3. Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. Horiuchi, A., Williams, K.R., Kurihara, T., Nairn, A.C., Greengard, P. J. Biol. Chem. (1990) [Pubmed]
  4. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova, I., Horiuchi, A., Snyder, G.L., Girault, J.A., Czernik, A.J., Shao, L., Ramabhadran, R., Greengard, P., Nairn, A.C. J. Neurochem. (2001) [Pubmed]
  5. ARPP-16 mRNA is up-regulated in the longissimus muscle of pigs possessing an elevated growth rate. Janzen, M.A., Kuhlers, D.L., Jungst, S.B., Louis, C.F. J. Anim. Sci. (2000) [Pubmed]
  6. Expression of ARPP-16/19 in rat denervated skeletal muscle. Yoshikawa, A., Mitsuhashi, H., Sasagawa, N., Tsukahara, T., Hayashi, Y., Nishino, I., Goto, Y., Ishiura, S. J. Biochem. (2003) [Pubmed]
  7. Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells. Chin, L.S., Singh, S.K., Wang, Q., Murray, S.F. J. Biomed. Sci. (2000) [Pubmed]
  8. Cloning, sequence, and developmental expression analysis of C4-2, a potential brain tumor-suppressor gene. Sehgal, A., Ricks, S., Keener, C., Boynton, A.L., Young, R.F., Vermeulen, S.S., Yonemura, K.S., Kohler, E.P., Aldape, H.C., Simrell, C.R., Murphy, G.P. Journal of surgical oncology. (1997) [Pubmed]
 
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