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CEP250  -  centrosomal protein 250kDa

Homo sapiens

Synonyms: 250 kDa centrosomal protein, C-NAP1, C-Nap1, CEP2, CNAP1, ...
 
 
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High impact information on CEP250

 

Biological context of CEP250

  • Based on these findings, we propose a model implicating both Nek2 and C-Nap1 in the regulation of centriole-centriole cohesion during the cell cycle [3].
  • Whereas C-Nap1 was concentrated at centrosomes in all interphase cells, immunoreactivity at mitotic spindle poles was strongly diminished [3].
  • Phosphorylation of C-Nap1 at the G2/M transition may trigger its displacement from centrioles, promoting their separation and subsequent bipolar spindle formation [4].
  • The auditory brainstem response (ABR), electrocochleogram (ECochG) and direct recording from the auditory nerve (CNAP) were compared [5].
  • The purpose of this study was to determine in man the effect on the breathing pattern of continuous positive (CPAP), continuous negative (CNAP) and positive end-expiratory (PEEP) airway pressure during air breathing and CO2 inhalation [6].
 

Anatomical context of CEP250

  • Recently, we have proposed that C-Nap1, a novel centrosomal protein, is part of a structure linking parental centrioles in a cell cycle-regulated manner [2].
  • Overexpression of full-length C-Nap1 in human U2OS cells caused the formation of large structures that embedded the centrosome and impaired its microtubule nucleation activity [7].
  • CNAP was compared with invasive radial artery pressure recordings from the opposite wrist in 22 high-risk surgical patients with an inter-arm oscillometric mean arterial pressure difference < or = 10 mm Hg [8].
  • The CNAP is especially useful for the identification of the auditory nerve [5].
  • Cochlear nerve function is assessed by recording the ABR from ear canal and scalp electrodes or the CNAP with an electrode placed directly on the nerve at the brain stem root entry zone [9].
 

Enzymatic interactions of CEP250

  • Finally, the COOH-terminal domain of C-Nap1 could readily be phosphorylated by Nek2 in vitro, as well as after coexpression of the two proteins in vivo [3].
 

Other interactions of CEP250

 

Analytical, diagnostic and therapeutic context of CEP250

References

  1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. Bahe, S., Stierhof, Y.D., Wilkinson, C.J., Leiss, F., Nigg, E.A. J. Cell Biol. (2005) [Pubmed]
  2. The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. Mayor, T., Stierhof, Y.D., Tanaka, K., Fry, A.M., Nigg, E.A. J. Cell Biol. (2000) [Pubmed]
  3. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. Fry, A.M., Mayor, T., Meraldi, P., Stierhof, Y.D., Tanaka, K., Nigg, E.A. J. Cell Biol. (1998) [Pubmed]
  4. Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. Faragher, A.J., Fry, A.M. Mol. Biol. Cell (2003) [Pubmed]
  5. Electrophysiological monitoring during acoustic neuroma and other posterior fossa surgery. Linden, R.D., Tator, C.H., Benedict, C., Charles, D., Mraz, V., Bell, I. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1988) [Pubmed]
  6. The influence on the breathing pattern in man of moderate levels of continuous positive and negative airway pressure and of positive end-expiratory pressure during air and CO2 inhalation. Ellingsen, I. Acta Physiol. Scand. (1990) [Pubmed]
  7. The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. Mayor, T., Hacker, U., Stierhof, Y.D., Nigg, E.A. J. Cell. Sci. (2002) [Pubmed]
  8. Radial artery tonometry: moderately accurate but unpredictable technique of continuous non-invasive arterial pressure measurement. Weiss, B.M., Spahn, D.R., Rahmig, H., Rohling, R., Pasch, T. British journal of anaesthesia. (1996) [Pubmed]
  9. Intraoperative monitoring of facial and cochlear nerves during acoustic neuroma surgery. Yingling, C.D., Gardi, J.N. Otolaryngol. Clin. North Am. (1992) [Pubmed]
 
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