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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHKB  -  choline kinase beta

Homo sapiens

 
 
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High impact information on CHKB

  • Glutamate-dependent transcriptional regulation of the chkbp gene: signaling mechanisms [1].
  • Chkl regulation pathways, DNA MMR and p73, as well as altered apoptotic cell death involved in the cell resistance toward DNA damaging agents will be reviewed in this article [2].
  • BACKGROUND: Chkl is a checkpoint gene that is activated after DNA damage [3].
  • In HL-60 cells transfected with chk1 antisense chain, the G2/M phase arrest was attenuated and the cells in G2/M phase were accounted for 38.42%, significantly lower than those of the cells transfected with chkl sense chain (54.64%, 0.005 < P < 0.01) [4].
  • For example, the sequence of a clone for KIAA1670 indicated that the CHKL and CPT1B genes were co-transcribed as a contiguous transcript without making both the protein-coding regions fused [5].

References

  1. Glutamate-dependent transcriptional regulation of the chkbp gene: signaling mechanisms. Aguirre, A., López-Bayghen, E., Ortega, A. J. Neurosci. Res. (2002) [Pubmed]
  2. Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance. Hapke, G., Yin, M.B., Rustum, Y.M. Cancer Metastasis Rev. (2001) [Pubmed]
  3. Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. Luo, Y., Rockow-Magnone, S.K., Joseph, M.K., Bradner, J., Butler, C.C., Tahir, S.K., Han, E.K., Ng, S.C., Severin, J.M., Gubbins, E.J., Reilly, R.M., Rueter, A., Simmer, R.L., Holzman, T.F., Giranda, V.L. Anticancer Res. (2001) [Pubmed]
  4. Apoptotic sensitivity to irradiation increased after transfection of chk1 antisense chain to HL-60 cell line. Tang, Y., Liu, W., Zhou, J., Gao, Q., Wu, J. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  5. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa, M., Nagase, T., Murahashi, Y., Kikuno, R., Ohara, O. DNA Res. (2001) [Pubmed]
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