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Gene Review

Pou4f1  -  POU class 4 homeobox 1

Rattus norvegicus

Synonyms: Brain-3A, Brain-specific homeobox/POU domain protein 3A, Brn-3, Brn-3A, Brn3, ...
 
 
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Disease relevance of Pou4f1

 

High impact information on Pou4f1

 

Biological context of Pou4f1

 

Anatomical context of Pou4f1

  • A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons [1].
 

Analytical, diagnostic and therapeutic context of Pou4f1

  • Using real-time PCR, we show that regulation of Brn-3 expression occurred at the transcriptional level [5].
  • In situ hybridization showed that most DRG neurons express Brn3a whereas only a small subset of neurons expresses Brn3c [1].

References

  1. A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons. Ninkina, N.N., Stevens, G.E., Wood, J.N., Richardson, W.D. Nucleic Acids Res. (1993) [Pubmed]
  2. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Li, P., He, X., Gerrero, M.R., Mok, M., Aggarwal, A., Rosenfeld, M.G. Genes Dev. (1993) [Pubmed]
  3. Regulation of expression of the neuronal POU protein Oct-2 by nerve growth factor. Wood, J.N., Lillycrop, K.A., Dent, C.L., Ninkina, N.N., Beech, M.M., Willoughby, J.J., Winter, J., Latchman, D.S. J. Biol. Chem. (1992) [Pubmed]
  4. A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. Lillycrop, K.A., Budrahan, V.S., Lakin, N.D., Terrenghi, G., Wood, J.N., Polak, J.M., Latchman, D.S. Nucleic Acids Res. (1992) [Pubmed]
  5. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. Weishaupt, J.H., Klöcker, N., Bähr, M. J. Mol. Neurosci. (2005) [Pubmed]
 
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