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Gene Review:

PASD1 - PAS domain containing 1

Homo sapiens

Synonyms: CT63, Cancer/testis antigen 63, OX-TES-1, OXTES1, PAS domain-containing protein 1

Liggins, A.P. et al., Guinn, B.A. et al., Quiroga, T. et al., Khadaroo, R. et al., Narikawa, R. et al., et al.

Liggins, Brown, Asker, Pulford, Banham, Guinn, Bland, Lodi, Liggins, Tobal, Petters, Wells, Banham, Mufti, Quiroga, Goycoolea, Giesen, Morales, Muñoz, Aranda, Rodríguez, Panes, Martínez, Pereira, Mezzano,

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Disease relevance of PASD1

PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy [1].
PASD1 has potential for lymphoma vaccine development that may also be widely applicable to other tumour types [2].
They showed features of a macrocystic serous adenoma of the pancreas that were characterized by a small number of large cystic cavities lined by a single layer of non-mucus secreting, PAS-positive and PASD-negative cuboidal epithelial cells [3].
Molecular evolution of PAS domain-containing proteins of filamentous cyanobacteria through domain shuffling and domain duplication [4].
We measured thrombin generation in platelet-poor plasma (TG-PPP) in 206 patients with a clinically unequivocal bleeding tendency: 45 with von Willebrand disease (vWD), 49 with platelet aggregation/secretion defects (PASD), 10 with a combination of both and 102 who did not fit the diagnostic criteria for any known haemostatic disorder [5].

High impact information on PASD1

The PASD1-predicted protein contains a PAS domain that, together with a putative leucine zipper and nuclear localisation signal, suggests it encodes a transcription factor [2].
Here we report that the OX-TES-1 SEREX antigen, which showed immunological reactivity with serum from four out of 10 diffuse large B-cell lymphoma (DLBCL) patients, is encoded by a novel gene, PAS domain containing 1 (PASD1) [2].
RT-PCR analysis indicated that we had identified three antigens which were expressed in patient bone marrow (BM) and peripheral blood (PB) but not in normal donor samples (PASD1, SSX2IP, and GRINL1A) [6].
Antigen presentation assays using monocyte-derived dendritic cells (mo-DCs) showed that PASD1 could stimulate autologous T-cell responses, suggesting that PASD1 could be a promising target for future immunotherapy clinical trials [6].

Anatomical context of PASD1

Expression of PASD1 mRNA was restricted to normal testis, while frequent expression was observed in solid tumours (25 out of 68), thus fulfilling the criteria for a novel cancer testis antigen [2].

Analytical, diagnostic and therapeutic context of PASD1

Real-time PCR (RQ-PCR) confirmed the restricted expression of PASD1 in normal donor organs [6].

References

PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy. Cooper, C.D., Liggins, A.P., Ait-Tahar, K., Roncador, G., Banham, A.H., Pulford, K. Leukemia (2006) [Pubmed]
A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. Liggins, A.P., Brown, P.J., Asker, K., Pulford, K., Banham, A.H. Br. J. Cancer (2004) [Pubmed]
Macrocystic serous adenoma of the pancreas. Khadaroo, R., Knetman, N., Joy, S., Nguyen, G.K. Pathol. Res. Pract. (2002) [Pubmed]
Molecular evolution of PAS domain-containing proteins of filamentous cyanobacteria through domain shuffling and domain duplication. Narikawa, R., Okamoto, S., Ikeuchi, M., Ohmori, M. DNA Res. (2004) [Pubmed]
Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucocutaneous haemorrhages. Quiroga, T., Goycoolea, M., Giesen, P.L., Morales, M., Muñoz, B., Aranda, E., Rodríguez, S., Panes, O., Martínez, C., Pereira, J., Mezzano, D. Pathophysiol. Haemost. Thromb. (2003) [Pubmed]
Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. Guinn, B.A., Bland, E.A., Lodi, U., Liggins, A.P., Tobal, K., Petters, S., Wells, J.W., Banham, A.H., Mufti, G.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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