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Hipk2  -  homeodomain interacting protein kinase 2

Mus musculus

Synonyms: 1110014O20Rik, B230339E18Rik, Homeodomain-interacting protein kinase 2, Nbak1, Nuclear body-associated kinase 1, ...
 
 
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High impact information on Hipk2

 

Biological context of Hipk2

 

Anatomical context of Hipk2

 

Associations of Hipk2 with chemical compounds

  • Here we demonstrate that human HIPK2 is small ubiquitin-related modifier-1 (SUMO-1)-modified in vitro and in vivo at lysine residue 25, a SUMO consensus modification motif conserved in human and mouse HIPK family proteins [7].
  • Stable expression of HIPK2 in U2OS cells enhanced the cisplatin response of sub-G(1) and G(2)/M populations, and it also increased the apoptotic response to cisplatin and adriamycin as demonstrated by fluorescence-activated cell sorter and 4',6-diamidino-2-phenylindole-staining analyses [8].
  • Here we identified the human serine/threonine kinase HIPK2 as a novel member of the DYRK kinase subfamily [9].
 

Regulatory relationships of Hipk2

  • HIPK2-induced apoptosis is caspase-dependent, is inhibited by overexpression of Bcl-2 and Bcl-W, and fails to occur in Bax-deficient neurons [6].
 

Other interactions of Hipk2

 

Analytical, diagnostic and therapeutic context of Hipk2

References

  1. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. D'Orazi, G., Cecchinelli, B., Bruno, T., Manni, I., Higashimoto, Y., Saito, S., Gostissa, M., Coen, S., Marchetti, A., Del Sal, G., Piaggio, G., Fanciulli, M., Appella, E., Soddu, S. Nat. Cell Biol. (2002) [Pubmed]
  2. Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. Wiggins, A.K., Wei, G., Doxakis, E., Wong, C., Tang, A.A., Zang, K., Luo, E.J., Neve, R.L., Reichardt, L.F., Huang, E.J. J. Cell Biol. (2004) [Pubmed]
  3. Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Isono, K., Nemoto, K., Li, Y., Takada, Y., Suzuki, R., Katsuki, M., Nakagawara, A., Koseki, H. Mol. Cell. Biol. (2006) [Pubmed]
  4. Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis. Cecchinelli, B., Lavra, L., Rinaldo, C., Iacovelli, S., Gurtner, A., Gasbarri, A., Ulivieri, A., Del Prete, F., Trovato, M., Piaggio, G., Bartolazzi, A., Soddu, S., Sciacchitano, S. Mol. Cell. Biol. (2006) [Pubmed]
  5. Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. Kim, E.A., Noh, Y.T., Ryu, M.J., Kim, H.T., Lee, S.E., Kim, C.H., Lee, C., Kim, Y.H., Choi, C.Y. J. Biol. Chem. (2006) [Pubmed]
  6. Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons. Doxakis, E., Huang, E.J., Davies, A.M. Curr. Biol. (2004) [Pubmed]
  7. Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. Hofmann, T.G., Jaffray, E., Stollberg, N., Hay, R.T., Will, H. J. Biol. Chem. (2005) [Pubmed]
  8. Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. Kim, E.J., Park, J.S., Um, S.J. J. Biol. Chem. (2002) [Pubmed]
  9. Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34. Hofmann, T.G., Mincheva, A., Lichter, P., Dröge, W., Schmitz, M.L. Biochimie (2000) [Pubmed]
  10. Molecular cloning of the cDNA of canine homeodomain-interacting protein kinase 2. Lee, S.Y., Chung, J.Y., Shin, I.S., Choi, E.W., Hwang, C.Y., Youn, H.Y., Han, H.R. J. Vet. Sci. (2005) [Pubmed]
 
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