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Oas1a  -  2'-5' oligoadenylate synthetase 1A

Rattus norvegicus

Synonyms: (2-5')oligo(A) synthase 1A, 2'-5'-oligoadenylate synthase 1A, 2-5A synthase 1A, Oas1, Oas1g
 
 
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Disease relevance of Oas1

  • The distribution of rabies virus, interferon and interferon-mediated enzymes, pppA(2'p5'A)n synthetase (2-5A synthetase) and poly(rI) . poly(rC)-Sepharose-bound protein kinase, was studied in different regions of the brains of rabies virus-infected rats [1].
 

High impact information on Oas1

 

Biological context of Oas1

  • Thus, the activity of two IFN-induced enzymes known to be part of the system-(2'-5') oligoadenylate synthetase (2-5A synthetase) and double-stranded RNA-activated protein kinase as well as the expression of 2-5A synthetase coding genes were examined during myogenesis [5].
  • Treatment of these cells for 3 days with 450 international units (IU)/ml of IFN followed by its removal, resulted in a gradual increase in all parameters associated with cell growth while the 2-5A-synthetase activity was reduced to its normal level [6].
 

Anatomical context of Oas1

  • Relying on these alternative biological responses, we studied the changes in 2-5A synthetase activity and its 43 kDa isoform expression in the course of differentiation and death of PC12 cells [4].
  • In pancreatic islets and RIN cells, the 2-5A synthetase enzyme generated dimers and trimers of 2',5'-oligoadenylates [7].
  • In rat skeletal muscle cultures which differentiate to form myotubes, the level of both 2-5A-synthetase and protein kinase activities was transiently elevated, reaching a peak at 3 days followed by a decrease to background levels [6].
  • The interferon (IFN)-dependent 2',5'-oligoadenylate synthetase (2-5A synthetase), which produces 2',5'-oligoadenylates from ATP, was analyzed in homogenates of isolated peripheral blood lymphocytes (PBL) from BB and Sprague-Dawley rats, man, sheep, and beagle dog [8].
 

Associations of Oas1 with chemical compounds

 

Other interactions of Oas1

 

Analytical, diagnostic and therapeutic context of Oas1

  • Western blot analysis of 2-5A synthetase proteins in untreated primary muscle cultures showed that the major species synthesized in these cells was the 43-kDa isoform of the enzyme [2].

References

  1. Distribution of rabies virus, interferon and interferon-mediated enzymes in the brains of virus-infected rats. Marcovistz, R., Hovanessian, A.G., Tsiang, H. J. Gen. Virol. (1984) [Pubmed]
  2. Interruption of myogenesis by transforming growth factor beta 1 or EGTA inhibits expression and activity of the myogenic-associated (2'-5') oligoadenylate synthetase and PKR. Salzberg, S., Mandelboim, M., Zalcberg, M., Shainberg, A., Mandelbaum M [corrected to Mandelboim, M. Exp. Cell Res. (1995) [Pubmed]
  3. Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity. Birnbaum, M., Shainberg, A., Salzberg, S. Virology (1993) [Pubmed]
  4. Expression and activity of 2-5A synthetase in the course of differentiation and apoptosis of PC12 cells. Lopp, A., Kuusksalu, A., Samuel, K., Kelve, M. Cytokine (2000) [Pubmed]
  5. Activation of the interferon system during myogenesis in vitro. Birnbaum, M., Trink, B., Shainberg, A., Salzberg, S. Differentiation (1990) [Pubmed]
  6. Involvement of interferon-system in the regulation of cell growth and differentiation. Salzberg, S., Hacohen, D., David, S., Dovrat, S., Ahwan, S., Gamliel, H., Birnbaum, M. Scanning Microsc. (1990) [Pubmed]
  7. Interferon stimulates the expression of 2',5'-oligoadenylate synthetase and MHC class I antigens in insulin-producing cells. Bonnevie-Nielsen, V., Gerdes, A.M., Fleckner, J., Petersen, J.S., Michelsen, B., Dyrberg, T. J. Interferon Res. (1991) [Pubmed]
  8. Lymphocytic 2',5'-oligoadenylate synthetase is insensitive to dsRNA and interferon stimulation in autoimmune BB rats. Bonnevie-Nielsen, V., Husum, G., Kristiansen, K. J. Interferon Res. (1991) [Pubmed]
  9. Effect of estrogen administration on rat liver 2-5A synthetase activity. Smekens, M., Dumont, J.E., Degeyter, A., Galand, P. Biochim. Biophys. Acta (1986) [Pubmed]
 
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