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Gene Review:

Serpinb3a - serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: 1110001H02Rik, 1110013A16Rik, Scca2, Serpinb4, Sqn5

Sakata, Y. et al., Bartuski, A.J. et al.

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High impact information on Serpinb3a

Unlike the SCCAs, however, Scca2 was detected also in the gastrointestinal tract [1].
Fluorescence in situ hybridization revealed that the Scca2 mapped near Bcl2 on mouse chromosome 1 [1].
Serpinb3a (SQN-5) and Serpinb3b, but not Serpinb3c, were functional, inhibiting both serine and cysteine proteinases with different inhibitory profiles due to the difference of two amino acids in their reactive site loops [2].
Serpinb3a was ubiquitously expressed in most tissues, whereas expression of Serpinb3b was limited to keratinocytes [2].

Anatomical context of Serpinb3a

Keratinocytes secreted both SCCA-related proteins, Serpinb3a and Serpinb3b [2].

References

A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Bartuski, A.J., Kamachi, Y., Schick, C., Massa, H., Trask, B.J., Silverman, G.A. Genomics (1998) [Pubmed]
Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Sakata, Y., Arima, K., Takeshita, K., Takai, T., Aoki, S., Ogawa, H., Sugihara, H., Fujimoto, K., Izuhara, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AT1G47710	Arabidopsis thaliana
AT1G64010	Arabidopsis thaliana
AT2G35580	Arabidopsis thaliana
SRP3	Arabidopsis thaliana
AT1G62170	Arabidopsis thaliana
AT1G62160	Arabidopsis thaliana
SRP2	Arabidopsis thaliana
AT2G26390	Arabidopsis thaliana
AT2G25240	Arabidopsis thaliana
AT3G45220	Arabidopsis thaliana
LOC786410	Bos taurus
SERPINB4	Bos taurus
LOC786348	Bos taurus
LOC511106	Bos taurus
LOC100337240	Bos taurus
srp-8	Caenorhabditis elegans
srp-7	Caenorhabditis elegans
srp-1	Caenorhabditis elegans
srp-6	Caenorhabditis elegans
srp-2	Caenorhabditis elegans
srp-3	Caenorhabditis elegans
srp-5	Caenorhabditis elegans
SERPINB4	Canis lupus familiaris
Spn28Db	Drosophila melanogaster
Spn28F	Drosophila melanogaster
Spn38F	Drosophila melanogaster
Spn28B	Drosophila melanogaster
Spn28Da	Drosophila melanogaster
Spn42De	Drosophila melanogaster
Spn42Dd	Drosophila melanogaster
OVALX	Gallus gallus
OVAL	Gallus gallus
OVALY	Gallus gallus
SERPINB4	Homo sapiens
SERPINB3	Macaca mulatta
SERPINB4	Macaca mulatta
Os03g0610650	Oryza sativa Japonica Group
Os03g0610700	Oryza sativa Japonica Group
Os03g0610800	Oryza sativa Japonica Group
SERPINB4	Pan troglodytes
Serpinb3a	Rattus norvegicus
LOC100490314	Xenopus (Silurana) tropicalis

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