Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Uqcrc1 - ubiquinol-cytochrome c reductase core...

Mus musculus

Synonyms: 1110032G10Rik, Complex III subunit 1, Core protein I, Cytochrome b-c1 complex subunit 1, mitochondrial, Ubiquinol-cytochrome-c reductase complex core protein 1

Kriaucionis, S. et al.

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Disease relevance of Uqcrc1

A causal link between Uqcrc1 gene overexpression and enhanced complex III activity was established in neuroblastoma cells [1].

High impact information on Uqcrc1

Uqcrc1 encodes a subunit of mitochondrial respiratory complex III, and isolated mitochondria from the Mecp2-null brain showed elevated respiration rates associated with respiratory complex III and an overall reduction in coupling [1].

Physical interactions of Uqcrc1

Chromatin immunoprecipitation demonstrated that MeCP2 interacts with the Uqcrc1 promoter [1].

Analytical, diagnostic and therapeutic context of Uqcrc1

Using the Mecp2-null mouse (an animal model for RTT) and differential display, we found that mice with neurological symptoms overexpress the nuclear gene for ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1) [1].

References

Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Kriaucionis, S., Paterson, A., Curtis, J., Guy, J., Macleod, N., Bird, A. Mol. Cell. Biol. (2006) [Pubmed]

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