Disease relevance of Uqcrc1

• A causal link between Uqcrc1 gene overexpression and enhanced complex III activity was established in neuroblastoma cells [1].

High impact information on Uqcrc1

• Uqcrc1 encodes a subunit of mitochondrial respiratory complex III, and isolated mitochondria from the Mecp2-null brain showed elevated respiration rates associated with respiratory complex III and an overall reduction in coupling [1].

Physical interactions of Uqcrc1

• Chromatin immunoprecipitation demonstrated that MeCP2 interacts with the Uqcrc1 promoter [1].

Analytical, diagnostic and therapeutic context of Uqcrc1

• Using the Mecp2-null mouse (an animal model for RTT) and differential display, we found that mice with neurological symptoms overexpress the nuclear gene for ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1) [1].

References