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Gene Review

RAB21  -  RAB21, member RAS oncogene family

Homo sapiens

Synonyms: KIAA0118, Ras-related protein Rab-21
 
 
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Disease relevance of RAB21

  • We have identified a novel rice gene, called RAB 21, which is induced when plants are subject to water-stress [1].
  • Early endosome localisation for Rab21 was confirmed in a hepatoma cell line that allowed analysis of the subcellular distribution of the endogenous protein [2].
 

High impact information on RAB21

  • Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins [3].
  • Knock down of Rab21 impairs integrin-mediated cell adhesion and motility, whereas its overexpression stimulates cell migration and cancer cell adhesion to collagen and human bone [3].
  • Induction of RAB 21 mRNA accumulation by ABA is rapid (less than 15 min in suspension cells) and does not require protein synthesis, indicating that preformed nuclear and/or cytosolic factors mediate the response to this hormone [1].
  • We have characterized the RAB 21 gene by determining the complete nucleotide sequence of a nearly full-length cDNA and corresponding genomic copy, and by mapping the start site of its major transcript [1].
  • RAB 21 mRNA and protein accumulate in rice embryos, leaves, roots and callus-derived suspension cells upon treatment with NaCl (200 mM) and/or the plant hormone abscisic acid (10 microM ABA) [1].
 

Biological context of RAB21

 

Anatomical context of RAB21

  • Collectively, our data provide the first characterisation of Rab21 function in early endosome dynamics [2].

References

  1. Abscisic acid and water-stress induce the expression of a novel rice gene. Mundy, J., Chua, N.H. EMBO J. (1988) [Pubmed]
  2. A role for the small GTPase Rab21 in the early endocytic pathway. Simpson, J.C., Griffiths, G., Wessling-Resnick, M., Fransen, J.A., Bennett, H., Jones, A.T. J. Cell. Sci. (2004) [Pubmed]
  3. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. Pellinen, T., Arjonen, A., Vuoriluoto, K., Kallio, K., Fransen, J.A., Ivaska, J. J. Cell Biol. (2006) [Pubmed]
 
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