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Gene Review:

Ajap1 - adherens junction associated protein 1

Mus musculus

Synonyms: Adherens junction-associated protein 1, Gm573, LOC230959

Miller, J.R. et al., Campbell, M. et al.

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High impact information on Ajap1

Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo [1].
In addition, epithelial cells in the archenteron display a significant decrease in adherens junction-associated beta-catenin levels as they undergo convergent-extension movements [1].
The epithelial-mesenchymal conversion that characterizes the ingression of both primary and secondary mesenchyme cells coincides with a rapid and dramatic loss of adherens junction-associated beta-catenin [1].
We have found an up-regulation of the tight junction and adherens junction associated protein Zonula Occludens-1 (ZO-1) in the neural retina of 6-week-old Rho(-/-) knockout mice compared with 6-week-old Wild-Type (WT) mice [2].

References

Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. Miller, J.R., McClay, D.R. Dev. Biol. (1997) [Pubmed]
Aberrant retinal tight junction and adherens junction protein expression in an animal model of autosomal dominant Retinitis pigmentosa: the Rho(-/-) mouse. Campbell, M., Humphries, M., Kennan, A., Kenna, P., Humphries, P., Brankin, B. Exp. Eye Res. (2006) [Pubmed]

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