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Cyp3a2  -  cytochrome P450, family 3, subfamily a,...

Rattus norvegicus

Synonyms: CYPIIIA2, Cyp3a-2, Cyp3a11, Cytochrome P450 3A2, Cytochrome P450-PCN2, ...
 
 
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Disease relevance of Cyp3a11

 

High impact information on Cyp3a11

 

Biological context of Cyp3a11

 

Anatomical context of Cyp3a11

 

Associations of Cyp3a11 with chemical compounds

 

Other interactions of Cyp3a11

 

Analytical, diagnostic and therapeutic context of Cyp3a11

References

  1. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Eberhart, D.C., Gemzik, B., Halvorson, M.R., Parkinson, A. Mol. Pharmacol. (1991) [Pubmed]
  2. Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Gonzalez, F.J., Song, B.J., Hardwick, J.P. Mol. Cell. Biol. (1986) [Pubmed]
  3. Imprinting of hepatic microsomal cytochrome P-450 enzyme activities and cytochrome P-450IIC11 by peripubertal administration of testosterone in female rats. Cadario, B.J., Bellward, G.D., Bandiera, S., Chang, T.K., Ko, W.W., Lemieux, E., Pak, R.C. Mol. Pharmacol. (1992) [Pubmed]
  4. Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect. Sukata, T., Uwagawa, S., Ozaki, K., Ogawa, M., Nishikawa, T., Iwai, S., Kinoshita, A., Wanibuchi, H., Imaoka, S., Funae, Y., Okuno, Y., Fukushima, S. Int. J. Cancer (2002) [Pubmed]
  5. The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats. Smith, B.J., Sipes, I.G., Stevens, J.C., Halpert, J.R. Carcinogenesis (1990) [Pubmed]
  6. A gene structure of testosterone 6 beta-hydroxylase (P450IIIA). Miyata, M., Nagata, K., Yamazoe, Y., Kato, R. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  7. Enhanced inhibition of microsomal cytochrome P450 3A2 in rat liver during diltiazem biotransformation. Murray, M., Butler, A.M. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  8. Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections. Desjardins, J.P., Sproat, B.S., Beijer, B., Blaschke, M., Dunkel, M., Gerdes, W., Ludwig, J., Reither, V., Rupp, T., Iversen, P.L. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  9. Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats. Arora, V., Knapp, D.C., Reddy, M.T., Weller, D.D., Iversen, P.L. Journal of pharmaceutical sciences. (2002) [Pubmed]
  10. A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. Yamazoe, Y., Murayama, N., Shimada, M., Yamauchi, K., Nagata, K., Imaoka, S., Funae, Y., Kato, R. J. Biochem. (1988) [Pubmed]
  11. Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. Nagata, K., Gonzalez, F.J., Yamazoe, Y., Kato, R. J. Biochem. (1990) [Pubmed]
  12. Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes. Takemoto, K., Yamazaki, H., Tanaka, Y., Nakajima, M., Yokoi, T. Xenobiotica (2003) [Pubmed]
  13. Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo. Brand, R.M., Hannah, T.L., Norris, J., Iversen, P.L. Antisense Nucleic Acid Drug Dev. (2001) [Pubmed]
  14. Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Sun, G., Thai, S.F., Lambert, G.R., Wolf, D.C., Tully, D.B., Goetz, A.K., George, M.H., Grindstaff, R.D., Dix, D.J., Nesnow, S. Toxicol. Lett. (2006) [Pubmed]
  15. Modulation of rat hepatic cytochromes P450 by chronic methapyrilene treatment. Wrighton, S.A., VandenBranden, M., Brown, T.J., Van Pelt, C.S., Thomas, P.E., Shipley, L.A. Biochem. Pharmacol. (1991) [Pubmed]
  16. Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo. Desjardins, J.P., Iversen, P.L. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  17. Impact of tamoxifen on peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11, cytochrome P450 3A2, and steroid 5 alpha-reductase. Chang, T.K., Chan, M.M., Holsmer, S.L., Bandiera, S.M., Bellward, G.D. Biochem. Pharmacol. (1996) [Pubmed]
  18. Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Ghosal, A., Sadrieh, N., Reik, L., Levin, W., Thomas, P.E. Arch. Biochem. Biophys. (1996) [Pubmed]
  19. Physiological regulation of P-glycoprotein, MRP1, MRP2 and cytochrome P450 3A2 during rat ontogeny. Rosati, A., Maniori, S., Decorti, G., Candussio, L., Giraldi, T., Bartoli, F. Dev. Growth Differ. (2003) [Pubmed]
  20. Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. Miyata, M., Nagata, K., Shimada, M., Yamazoe, Y., Kato, R. Arch. Biochem. Biophys. (1994) [Pubmed]
  21. Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system. Leakey, J.E., Cunny, H.C., Bazare, J., Webb, P.J., Feuers, R.J., Duffy, P.H., Hart, R.W. Mech. Ageing Dev. (1989) [Pubmed]
 
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