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Gene Review

LRP12  -  low density lipoprotein receptor-related...

Homo sapiens

Synonyms: FLJ12929, LRP-12, Low-density lipoprotein receptor-related protein 12, ST7, Suppressor of tumorigenicity 7 protein
 
 
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Disease relevance of LRP12

 

High impact information on LRP12

  • Northern analysis of 15 tumor cell lines derived from patients and 16 cell lines established from tumors formed in athymic mice by MSU-1.1 cells transformed in culture by various methods showed that 16 of the 31 cell lines have low or undetectable levels of ST7 mRNA [4].
  • Furthermore, Western blotting analysis using a specific anti-peptide antibody demonstrated that the level of ST7 protein is high in normal fibroblasts and low in 12 sarcoma-derived cell lines tested [4].
  • The ST7 gene is widely expressed in normal human tissues and is particularly abundant in human heart and skeletal muscle [4].
  • The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized [3].

References

  1. Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas. Garnis, C., Coe, B.P., Zhang, L., Rosin, M.P., Lam, W.L. Oncogene (2004) [Pubmed]
  2. ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix. Hooi, C.F., Blancher, C., Qiu, W., Revet, I.M., Williams, L.H., Ciavarella, M.L., Anderson, R.L., Thompson, E.W., Connor, A., Phillips, W.A., Campbell, I.G. Oncogene (2006) [Pubmed]
  3. Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer. Haddad, R., Vincent, J.B., Gryfe, R., Kim, H., Wen, J., Redston, M., Scherer, S.W., Gallinger, S. Cancer Lett. (2004) [Pubmed]
  4. Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines. Qing, J., Wei, D., Maher, V.M., McCormick, J.J. Oncogene (1999) [Pubmed]
 
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