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Gene Review

TNPO2  -  transportin 2

Homo sapiens

Synonyms: FLJ12155, IPO3, KPNB2B, Karyopherin beta-2b, TRN2, ...
 
 
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Disease relevance of TNPO2

  • The mechanisms by which IPO-3 vs. Bgp95 increase HIV-1 levels appear to be different [1].
  • Activation of DCs through IPO-3 receptors, and to a lesser extent Bgp95 ligation, upregulated HIV spread in these cells [1].
 

High impact information on TNPO2

 

Anatomical context of TNPO2

  • Studies of normal and neoplastic B cells suggest that mAbs IPO-3 and IPO-10 which recognize antigens are B lineage restricted [6].
  • Monoclonal antibodies (mAbs) IPO-3 and IPO-10 were generated following immunization of a BALB/c mice with human cell lines RPMI-1788 and Daudi respectively [6].
 

Associations of TNPO2 with chemical compounds

  • In vitro kinase assays revealed that IPO-3 has a protein kinase activity associated with it that is maintained even in Nonidet P-40 lysates [5].
 

Other interactions of TNPO2

  • Here we have investigated the subfamily of transportins that consists of Trn1 (or Kap beta2A) and two alternatively spliced Trn2 isoforms (Trn2a and Trn2b), also called Trn2 and Kap beta2B [7].
  • Finally, crosscompetition experiments demonstrated that HuR nucleocytoplasmic shuttling signal and M9 are imported along redundant pathways involving TRN1/2, substantiating the function of TRN2 in nuclear import [2].
 

Analytical, diagnostic and therapeutic context of TNPO2

References

  1. Immunodeficiency virus cDNA synthesis in resting T lymphocytes is regulated by T cell activation signals and dendritic cells. Polacino, P.S., Pinchuk, L.M., Sidorenko, S.P., Clark, E.A. J. Med. Primatol. (1996) [Pubmed]
  2. Transportin2 functions as importin and mediates nuclear import of HuR. Güttinger, S., Mühlhäusser, P., Koller-Eichhorn, R., Brennecke, J., Kutay, U. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Karyopherin beta 2B participates in mRNA export from the nucleus. Shamsher, M.K., Ploski, J., Radu, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. Blanc, V., Kennedy, S., Davidson, N.O. J. Biol. Chem. (2003) [Pubmed]
  5. Characterization of a cell surface glycoprotein IPO-3, expressed on activated human B and T lymphocytes. Sidorenko, S.P., Clark, E.A. J. Immunol. (1993) [Pubmed]
  6. Monoclonal antibodies IPO-3 and IPO-10 against human B cell differentiation antigens. Pinchouk, V.G., Sidorenko, S.P., Gluzman, D.F., Vetrova, E.P., Berdova, A.G., Schlapatskaya, L.N. Anticancer Res. (1988) [Pubmed]
  7. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. Rebane, A., Aab, A., Steitz, J.A. RNA (2004) [Pubmed]
 
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