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Zap70  -  zeta-chain (TCR) associated protein kinase 70

Rattus norvegicus

 
 
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High impact information on Zap70

  • Finally, partial or complete tyrosine phosphorylation of Zap70 was observed in alloantigen-specific T cell clones in response to tolerogenic versus immunogenic peptides, respectively [1].
  • These results suggested that TGF-beta-mediated inhibition of P56lck, P59fyn, and Zap-70 is likely due to an up-regulation of protein tyrosine phosphatases such as SHP-1 [2].
  • The decrease in P56lck, P59fyn kinase activity, and Zap-70 phosphorylation was prevented when T cells were stimulated with anti-CD3 in the presence of pervanadate, an inhibitor of PTP [2].

References

  1. Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals. Stepkowski, S.M., Kirken, R.A., Trawick, B.W., Wang, M., Tejpal, N., Wang, M.E., Tian, L., Clark, J., Kahan, B.D. Transplantation (2002) [Pubmed]
  2. TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells. Choudhry, M.A., Sir, O., Sayeed, M.M. Shock (2001) [Pubmed]
 
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