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Gene Review

nog3  -  noggin 3

Danio rerio

Synonyms: Noggin-3, SO:0000704
 
 
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High impact information on nog3

  • In the zygote, repression of ventralizing Bmp activity on the dorsal side through chordin and noggin is crucial for establishment of a dorsally located organizer [1].
  • We have ruled out zebrafish noggin homologues as candidates for the ogo gene, including a newly identified gene, nog1, which is specifically expressed in the gastrula organizer [2].
  • While single-copy noggin genes have been characterized in several vertebrate species, we report that the zebrafish genome harbors three noggin homologues [3].
  • Follistatin and noggin are excluded from the zebrafish organizer [4].
  • Conversely, increases in dorso-anterior mesoderm and neurectoderm were generated by injection of RNA encoding either a dominant-negative BMP receptor (delta BMPR) or noggin, as demonstrated by goosecoid and pax2 expression [5].

References

  1. Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Reim, G., Brand, M. Development (2006) [Pubmed]
  2. Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Miller-Bertoglio, V., Carmany-Rampey, A., Fürthauer, M., Gonzalez, E.M., Thisse, C., Thisse, B., Halpern, M.E., Solnica-Krezel, L. Dev. Biol. (1999) [Pubmed]
  3. Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo. Fürthauer, M., Thisse, B., Thisse, C. Dev. Biol. (1999) [Pubmed]
  4. Follistatin and noggin are excluded from the zebrafish organizer. Bauer, H., Meier, A., Hild, M., Stachel, S., Economides, A., Hazelett, D., Harland, R.M., Hammerschmidt, M. Dev. Biol. (1998) [Pubmed]
  5. A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish. Neave, B., Holder, N., Patient, R. Mech. Dev. (1997) [Pubmed]
 
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