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Gene Review

nog1  -  noggin 1

Danio rerio

Synonyms: Noggin-1, SO:0000704, fc23h06, wu:fc23h06, zNog1
 
 
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High impact information on nog1

  • In the zygote, repression of ventralizing Bmp activity on the dorsal side through chordin and noggin is crucial for establishment of a dorsally located organizer [1].
  • We show that this early restriction of Bmp gene expression, which occurs independently of noggin and chordin, is an essential step in the establishment of DV patterning [2].
  • Additionally, inhibition of BMP signalling by expressing noggin or a truncated, dominant negative BMP receptor prevents heart looping but allows the initial events of chamber specification and anteroposterior morphogenesis to occur [3].
  • We have ruled out zebrafish noggin homologues as candidates for the ogo gene, including a newly identified gene, nog1, which is specifically expressed in the gastrula organizer [4].
 

Other interactions of nog1

  • The establishment of dorsoventral (DV) patterning in vertebrate embryos depends on the morphogenic activity of a group of Tgfbeta superfamily members, the bone morphogenetic proteins (Bmps) (which specify ventral cell fates), and on their interaction with their dorsally secreted cognate inhibitors chordin and noggin [2].

References

  1. Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. Reim, G., Brand, M. Development (2006) [Pubmed]
  2. Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. Fürthauer, M., Van Celst, J., Thisse, C., Thisse, B. Development (2004) [Pubmed]
  3. A role for BMP signalling in heart looping morphogenesis in Xenopus. Breckenridge, R.A., Mohun, T.J., Amaya, E. Dev. Biol. (2001) [Pubmed]
  4. Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Miller-Bertoglio, V., Carmany-Rampey, A., Fürthauer, M., Gonzalez, E.M., Thisse, C., Thisse, B., Halpern, M.E., Solnica-Krezel, L. Dev. Biol. (1999) [Pubmed]
 
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