The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pvr  -  PDGF- and VEGF-receptor related

Drosophila melanogaster

Synonyms: 8222, CG8222, CT24332, DmVEGFR, Dmel\CG8222, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pvr


Biological context of Pvr

  • Flies hemizygous for the apoptotic genes hid, reaper and grim, or mutant for puckered which encodes a phosphatase that down-regulates the n-Jun-N terminal kinase pathway, lead to the same phenotypes as mutations in PVF1/PVR [4].
  • PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia [4].
  • PVR, the Drosophila homolog of the PDGF/VEGF receptor, has been implicated in border cell migration during oogenesis and hemocyte migration during embryogenesis [3].
  • In contrast, using both laser ablation and a novel wounding assay that allows localized treatment with inhibitory drugs, we show that PI3K is essential for hemocyte chemotaxis toward wounds and that Pvf signals and PDGF/VEGF receptor expression are not required for this rapid chemotactic response [5].
  • These results identify the PDGF/VEGF receptor homolog and one of its ligands as important players in Drosophila hematopoiesis [6].

Anatomical context of Pvr

  • We examined the roles of the Drosophila PDGF/VEGF receptor (PVR) in polarized epithelial cells, with specific emphasis on the wing disc epithelium [7].
  • Elevation of the level of full-length PVR also gave rise to prominent phenotypes, characterized by higher levels of actin microfilaments at the basolateral areas of the cells and irregular folding of the tissue [7].
  • Together, these results suggest that polarized PVR activation is necessary for the proper organization of the wing disc epithelium, by regulating the apical assembly of the actin cytoskeleton [7].
  • The Drosophila VEGF receptor homolog is expressed in hemocytes [8].
  • In Pvr mutants, a large fraction of the embryonic hemocyte population undergoes apoptosis, and the remaining blood cells cannibalistically phagocytose their dying peers [9].

Associations of Pvr with chemical compounds


Regulatory relationships of Pvr

  • We find that accumulation of Cortactin protein is positively regulated by PVR [11].

Other interactions of Pvr

  • Therefore, a complex combination of EGFR and PVR ligands together guide border cells to the oocyte [10].
  • We present evidence that Cortactin is one of the factors acting downstream of PVR and Src to stimulate F-actin accumulation [11].
  • We find that preventing hemocyte migration by removing the function of the Drosophila VEGF receptor homologue, Pvr, or by disrupting Rac1 function in these cells, inhibits condensation [12].
  • PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis [3].
  • In the case of Pvr and Alk, this phenotype also is accompanied by lamellocyte formation [13].

Analytical, diagnostic and therapeutic context of Pvr


  1. Developmental control of blood cell migration by the Drosophila VEGF pathway. Cho, N.K., Keyes, L., Johnson, E., Heller, J., Ryner, L., Karim, F., Krasnow, M.A. Cell (2002) [Pubmed]
  2. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Duchek, P., Somogyi, K., Jékely, G., Beccari, S., Rørth, P. Cell (2001) [Pubmed]
  3. PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. Ishimaru, S., Ueda, R., Hinohara, Y., Ohtani, M., Hanafusa, H. EMBO J. (2004) [Pubmed]
  4. PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia. Macías, A., Romero, N.M., Martín, F., Suárez, L., Rosa, A.L., Morata, G. Int. J. Dev. Biol. (2004) [Pubmed]
  5. Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. Wood, W., Faria, C., Jacinto, A. J. Cell Biol. (2006) [Pubmed]
  6. PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae. Munier, A.I., Doucet, D., Perrodou, E., Zachary, D., Meister, M., Hoffmann, J.A., Janeway, C.A., Lagueux, M. EMBO Rep. (2002) [Pubmed]
  7. Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization. Rosin, D., Schejter, E., Volk, T., Shilo, B.Z. Development (2004) [Pubmed]
  8. The Drosophila VEGF receptor homolog is expressed in hemocytes. Heino, T.I., Kärpänen, T., Wahlström, G., Pulkkinen, M., Eriksson, U., Alitalo, K., Roos, C. Mech. Dev. (2001) [Pubmed]
  9. The PDGF/VEGF receptor controls blood cell survival in Drosophila. Brückner, K., Kockel, L., Duchek, P., Luque, C.M., Rørth, P., Perrimon, N. Dev. Cell (2004) [Pubmed]
  10. Multiple EGFR ligands participate in guiding migrating border cells. McDonald, J.A., Pinheiro, E.M., Kadlec, L., Schupbach, T., Montell, D.J. Dev. Biol. (2006) [Pubmed]
  11. Cortactin modulates cell migration and ring canal morphogenesis during Drosophila oogenesis. Somogyi, K., Rørth, P. Mech. Dev. (2004) [Pubmed]
  12. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Olofsson, B., Page, D.T. Dev. Biol. (2005) [Pubmed]
  13. A directed screen for genes involved in Drosophila blood cell activation. Zettervall, C.J., Anderl, I., Williams, M.J., Palmer, R., Kurucz, E., Ando, I., Hultmark, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
WikiGenes - Universities