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HTRA2  -  HtrA serine peptidase 2

Gallus gallus

 
 
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Disease relevance of LOC395990

  • A monoclonal antibody has been raised against the serine protease, plasminogen activator (PA) produced by Rous sarcoma virus-transformed chick embryo fibroblasts (RSVCEF), and selected for its ability to inhibit the catalytic activity of PA [1].
  • Functional activity of eukaryotic signal sequences in Escherichia coli: the ovalbumin family of serine protease inhibitors [2].
  • The predicted 148.3-kDa protein product possesses the three domains that are typical of serine protease autotransporters of Enterobacteriaceae: an N-terminal signal sequence of 55 amino acids, a 111.8-kDa passenger domain containing a modified serine protease site (ATSGSG), and a C-terminal outer membrane translocator of 30.5 kDa [3].
  • A deletion mutant lacking the non-essential vaccinia virus gene K2L, a member of the serine protease inhibitor superfamily, was constructed [4].
  • These results on the IBDV VP4 confirm and extend our previous characterization of the IPNV VP4, delineating the birnavirus protease as a new type of viral serine protease [5].
 

Psychiatry related information on LOC395990

 

High impact information on LOC395990

 

Biological context of LOC395990

 

Anatomical context of LOC395990

 

Associations of LOC395990 with chemical compounds

  • Analysis of the primary structural features further characterized neuroserpin as a heparin-independent, functional inhibitor of a trypsin-like serine protease [10].
  • The enzyme is inactivated by the serine protease inhibitors diisopropyl fluorophosphate and 3,4-dichloroisocoumarin, but not by specific inhibitors of aspartic, thiol, or metalloproteases [19].
  • The serine protease trypsin mimics these actions in a dose-dependent fashion, whereas the proteolytically inactive thrombin derivatives diisopropyl fluorophosphate-thrombin (DIP-thrombin) and D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone-thrombin (PPACK-thrombin) are ineffective in this regard [20].
  • Wild-type and variant cystatin C are cysteine proteinase inhibitors which form concentration dependent inactive dimers; however, variant cystatin C dimerizes at lower concentrations and has an increased susceptibility to a serine protease [21].
  • Although the function of the insertion sequences is unknown, our molecular evolutionary analysis shows that these insertion sequences in beta APP have an evolutionarily close relationship with the inter-alpha-trypsin inhibitor or trypstatin, which inhibits the activity of tryptase, a novel membrane-bound serine protease in human T4+ lymphocytes [22].
 

Other interactions of LOC395990

  • Ovalbumin, the major protein in avian egg-white, is a non-inhibitory member of the serine protease inhibitor (serpin) superfamily [23].
  • This novel protease is composed of a short N-terminal cytoplasmic region followed by a transmembrane domain, a stem region with one SEA, two CUB and three LDLRa (low-density lipoprotein receptor domain class A) domains and a C-terminal catalytic serine protease domain [24].
 

Analytical, diagnostic and therapeutic context of LOC395990

References

  1. An anticatalytic monoclonal antibody to avian plasminogen activator: its effect on behavior of RSV-transformed chick fibroblasts. Sullivan, L.M., Quigley, J.P. Cell (1986) [Pubmed]
  2. Functional activity of eukaryotic signal sequences in Escherichia coli: the ovalbumin family of serine protease inhibitors. Belin, D., Guzman, L.M., Bost, S., Konakova, M., Silva, F., Beckwith, J. J. Mol. Biol. (2004) [Pubmed]
  3. A novel pathogenicity island integrated adjacent to the thrW tRNA gene of avian pathogenic Escherichia coli encodes a vacuolating autotransporter toxin. Parreira, V.R., Gyles, C.L. Infect. Immun. (2003) [Pubmed]
  4. A vaccinia serine protease inhibitor which prevents virus-induced cell fusion. Law, K.M., Smith, G.L. J. Gen. Virol. (1992) [Pubmed]
  5. Role of Ser-652 and Lys-692 in the protease activity of infectious bursal disease virus VP4 and identification of its substrate cleavage sites. Lejal, N., Da Costa, B., Huet, J.C., Delmas, B. J. Gen. Virol. (2000) [Pubmed]
  6. Perinatal leupeptin retards subsequent acquisition of a visual discrimination task in chicks. Deyo, R.A., Conner, R.L., Panksepp, J. Behavioral and neural biology. (1987) [Pubmed]
  7. Fibronectin-degrading proteases from the membranes of transformed cells. Chen, J.M., Chen, W.T. Cell (1987) [Pubmed]
  8. Phorbol ester-induced morphological changes in transformed chick fibroblasts: evidence for direct catalytic involvement of plasminogen activator. Quigley, J.P. Cell (1979) [Pubmed]
  9. Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte. Gershenfeld, H.K., Weissman, I.L. Science (1986) [Pubmed]
  10. Neuroserpin, an axonally secreted serine protease inhibitor. Osterwalder, T., Contartese, J., Stoeckli, E.T., Kuhn, T.B., Sonderegger, P. EMBO J. (1996) [Pubmed]
  11. An endoprotease homologous to the blood clotting factor X as a determinant of viral tropism in chick embryo. Gotoh, B., Ogasawara, T., Toyoda, T., Inocencio, N.M., Hamaguchi, M., Nagai, Y. EMBO J. (1990) [Pubmed]
  12. A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death. Houenou, L.J., Turner, P.L., Li, L., Oppenheim, R.W., Festoff, B.W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  13. Characterization of the avian pathogenic Escherichia coli hemagglutinin Tsh, a member of the immunoglobulin A protease-type family of autotransporters. Stathopoulos, C., Provence, D.L., Curtiss, R. Infect. Immun. (1999) [Pubmed]
  14. Thermodynamics of unfolding for Kazal-type serine protease inhibitors: entropic stabilization of ovomucoid first domain by glycosylation. DeKoster, G.T., Robertson, A.D. Biochemistry (1997) [Pubmed]
  15. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. Krueger, S.R., Ghisu, G.P., Cinelli, P., Gschwend, T.P., Osterwalder, T., Wolfer, D.P., Sonderegger, P. J. Neurosci. (1997) [Pubmed]
  16. Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix. Dallas, S.L., Rosser, J.L., Mundy, G.R., Bonewald, L.F. J. Biol. Chem. (2002) [Pubmed]
  17. A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors. Clarke, E.P., Cates, G.A., Ball, E.H., Sanwal, B.D. J. Biol. Chem. (1991) [Pubmed]
  18. Differential cytoskeletal changes during growth cone collapse in response to hSema III and thrombin. Fritsche, J., Reber, B.F., Schindelholz, B., Bandtlow, C.E. Mol. Cell. Neurosci. (1999) [Pubmed]
  19. A novel ATP-requiring protease from skeletal muscle that hydrolyzes non-ubiquitinated proteins. Fagan, J.M., Waxman, L. J. Biol. Chem. (1989) [Pubmed]
  20. Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization. Jones, L.G., McDonough, P.M., Brown, J.H. Mol. Pharmacol. (1989) [Pubmed]
  21. Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. Calero, M., Pawlik, M., Soto, C., Castaño, E.M., Sigurdsson, E.M., Kumar, A., Gallo, G., Frangione, B., Levy, E. J. Neurochem. (2001) [Pubmed]
  22. Evolutionary origin of a Kunitz-type trypsin inhibitor domain inserted in the amyloid beta precursor protein of Alzheimer's disease. Ikeo, K., Takahashi, K., Gojobori, T. J. Mol. Evol. (1992) [Pubmed]
  23. Crystal structure of uncleaved ovalbumin at 1.95 A resolution. Stein, P.E., Leslie, A.G., Finch, J.T., Carrell, R.W. J. Mol. Biol. (1991) [Pubmed]
  24. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Szabo, R., Netzel-Arnett, S., Hobson, J.P., Antalis, T.M., Bugge, T.H. Biochem. J. (2005) [Pubmed]
  25. Characterization of soybean trypsin inhibitor sensitive protease from unfertilized sea urchin eggs. Alliegro, M.C., Schuel, H. Biochemistry (1985) [Pubmed]
  26. Production and characterization of recombinant chicken insulin-like growth factor-II from Escherichia coli. Upton, Z., Francis, G.L., Kita, K., Wallace, J.C., Ballard, F.J. J. Mol. Endocrinol. (1995) [Pubmed]
 
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