High impact information on Pdi

• The protein disulfide isomerase (PDI)-related protein Wind is essential in Drosophila melanogaster, and is required for correct targeting of Pipe, an essential Golgi transmembrane 2-O-sulfotransferase [1].
• Mapping of a substrate binding site in the protein disulfide isomerase-related chaperone wind based on protein function and crystal structure [1].
• The beta-subunit is identical to protein disulphide isomerase (PDI), a multifunctional endoplasmic reticulum luminal polypeptide [2].
• A Drosophila gene that encodes a member of the protein disulfide isomerase/phospholipase C-alpha family [3].
• The bPDI protein shared less than 55% of the amino acid sequence homology with other reported PDIs. bPDI is most genetically similar to the D. melanogaster PDI [4].

Biological context of Pdi

• In this study, we analyze for the first time endoplasmic reticulum (ER) dynamics and organization during oogenesis and embryonic divisions of Drosophila melanogaster using a Protein Disulfide Isomerase (PDI) GFP chimera protein [5].

Analytical, diagnostic and therapeutic context of Pdi

• Time-lapse confocal microscopy on PDI transgenic embryos allowed us to characterize a rapid redistribution of the ER during the mitotic phases [5].

References