Disease relevance of MFAP1

• The gene for microfibril-associated protein-1 (MFAP1) is located several megabases centromeric to FBN1 and is not mutated in Marfan syndrome [1].
• CONCLUSIONS: MFAP represents an active regimen in the treatment of locally advanced bladder cancer with a moderate toxicity profile [2].

High impact information on MFAP1

• METHODS: The combination chemotherapy using sequential methotrexate and 5-fluorouracil scheduling, epirubicin and cisplatin (MFAP regimen) for locally advanced bladder cancer was evaluated in a neoadjuvant setting [2].
• Pseudoexfoliation material may be associated closely with elastic microfibrillar-associated glycoprotein as well as elastin [3].
• Pseudoexfoliative material contains an elastic microfibrillar-associated glycoprotein [4].

Biological context of MFAP1

• We have carried out MFAP1 mutation screening and gene expression analysis in 48 probands with MFS or related phenotypes who were selected for this study because their fibroblast cultures synthesized fibrillin at normal levels [1].

Other interactions of MFAP1

• Recently, the gene for microfibril-associated protein-1 (MFAP1, also called AMP) has been isolated and mapped to the 15q15-q21 region that overlaps the location of the FBN1 gene [1].

References