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Gene Review

MRPS7  -  mitochondrial ribosomal protein S7

Homo sapiens

Synonyms: 28S ribosomal protein S7, mitochondrial, MRP-S, MRP-S7, RP-S7, RPMS7, ...
 
 
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High impact information on MRPS7

  • The region contains genes for the 16S rRNA, a subunit of a plastid NAD(P)H dehydrogenase (ndhB), three transfer RNAs (trnA, trnI, trnV) as well as the gene coding for the ribosomal protein S7 (rps7) [1].
  • Also, when nerve endings had an Em more negative than -40 mV showed spontaneous activity in the form of mini-receptor potentials (mrps) [2].
  • As suggested by unaltered transcript stabilities during hyphal induction, this regulation occurs on the transcriptional level; a conserved 18 bp palindromic sequence (5'-TTAGGGCTATAGCCCTAA-3'), which is present in the promoter regions of the RPL39 and RPS7 genes, may be involved in regulation [3].
  • In contrast, C. albicans RPS7 was found to lack an intron, while both S. cerevisiae homologs are interrupted by single introns [3].
  • The gene cluster rps12/rps7/psi ndhB of the plastome from the holoparasitic plant Cuscuta europaea has been analysed at the nucleotide level [4].
 

Biological context of MRPS7

  • In addition, 7 strains (8%) had a MRPS phenotype, which had so far been described for S. suis capsular type 1 [5].
  • In three additional mitotypes of carrot, rps7 and cox1 are co-transcribed, but are present as single copies within the genome [6].
  • Multidrug resistance proteins (p-glycoprotein and mrps) are becoming increasingly important to explain the pharmacokinetics and action of drugs [7].
 

Analytical, diagnostic and therapeutic context of MRPS7

  • Northern and RT-PCR analyses revealed that rps7 and cox1 are co-transcribed and RNA-edited [6].

References

 
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