Disease relevance of FGFRL1

• Recombinant FGFRL1 protein was produced in a baculovirus system with intact disulfide bonds [1].

High impact information on FGFRL1

• Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris [2].
• Small amounts of the FGFRL1 mRNA were also detected in other tissues such as skeletal muscle and heart [1].
• Clones for a novel transmembrane receptor termed FGFRL1 were isolated from a subtracted, cartilage-specific cDNA library prepared from chicken sterna [1].
• The novel gene (FGFRL1) is located on human chromosome 4 band p16 in close proximity to the gene for FGFR3 [3].
• The IIIc isoforms of FGFR1 and 2 and the novel FGFR5 were expressed in the aorta, but expression of the FGF receptor 3 was not detected in cDNAs derived from aortic tissue [4].

Biological context of FGFRL1

• Since FGFRL1 appears to be involved in the control of cell proliferation and differentiation, its aberrant expression might contribute to the development and progression of ovarian tumors [5].
• In human beings, the FGFRL1 gene is located on chromosome 4, adjacent to the SPON2, CTBP1 and MEAEA genes [6].
• These results suggest that FGFR5 may provide a binding site for some other fibroblast growth factors and may regulate some pancreatic function [7].

Anatomical context of FGFRL1

• Among 23 adult human tissues, FGFR5 mRNA is preferentially expressed in the pancreas [7].
• Recombinant FGFR5 expressed in COS-7 cells is not secreted, but recombinant truncated FGFR5 lacking the predicted transmembrane domain is secreted [7].
• As demonstrated by in situ hybridization of 16-day-old embryos, the Fgfrl1 mRNA occurs in cartilaginous structures such as the primordia of bones and the permanent cartilage of the trachea, the ribs and the nose [8].

Associations of FGFRL1 with chemical compounds

• A unique feature of FGFR5 is that it does not contain an intracellular tyrosine kinase domain [9].

Analytical, diagnostic and therapeutic context of FGFRL1

• FGFRL1 was expressed preferentially in skeletal tissues as demonstrated by Northern blotting and in situ hybridization [1].

References