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ACER3  -  alkaline ceramidase 3

Homo sapiens

Synonyms: APHC, AlkCDase 3, Alkaline CDase 3, Alkaline ceramidase 3, Alkaline dihydroceramidase SB89, ...
 
 
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Disease relevance of PHCA

  • [14C]Polyhexyl cyanoacrylate nanoparticles (PHCA), with diameters between 200 and 300 nm, were injected intravenously into nude mice bearing a human osteosarcoma [1].
  • We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373) [2].
  • This study evaluates the hypertension screening component in one of the oldest and largest health promotion programs for the elderly in the United States, the Preventive Health Care for the Aging Program (PHCAP) in California. Our findings show that 26.7% of PHCAP participants had hypertensive readings on examination [3].
 

High impact information on PHCA

 

Biological context of PHCA

 

Anatomical context of PHCA

 

Analytical, diagnostic and therapeutic context of PHCA

  • Furthermore, during low-flow CPB, patients where CBFV becomes non-detectable and show a pattern of CBFV recovery similar to PHCA, cessation of cerebral perfusion must be considered [11].
  • To examine the effects of low-flow cardiopulmonary bypass (CPB) and circulatory arrest (PHCA) on cerebral pressure-flow velocity relationships, we studied 32 patients (< 9 mo of age) undergoing corrective cardiac procedures [11].
  • Northern blot analysis showed that aPHC was ubiquitously expressed, with the highest expression in placenta [4].

References

  1. Distribution of polyhexyl cyanoacrylate nanoparticles in nude mice bearing human osteosarcoma. Gipps, E.M., Arshady, R., Kreuter, J., Groscurth, P., Speiser, P.P. Journal of pharmaceutical sciences. (1986) [Pubmed]
  2. Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. Okino, N., Ichinose, S., Omori, A., Imayama, S., Nakamura, T., Ito, M. J. Biol. Chem. (1999) [Pubmed]
  3. Hypertension in elderly people in a preventive health program. Weiler, P.G., Lubben, J.E., Chi, I. American journal of preventive medicine. (1989) [Pubmed]
  4. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. Mao, C., Xu, R., Szulc, Z.M., Bielawska, A., Galadari, S.H., Obeid, L.M. J. Biol. Chem. (2001) [Pubmed]
  5. Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. Tani, M., Okino, N., Mitsutake, S., Tanigawa, T., Izu, H., Ito, M. J. Biol. Chem. (2000) [Pubmed]
  6. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. Bielawska, A., Greenberg, M.S., Perry, D., Jayadev, S., Shayman, J.A., McKay, C., Hannun, Y.A. J. Biol. Chem. (1996) [Pubmed]
  7. Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. Payne, S.G., Brindley, D.N., Guilbert, L.J. J. Cell. Physiol. (1999) [Pubmed]
  8. Identification of an alkaline ceramidase gene from Dermatophilus congolensis. García-Sánchez, A., Cerrato, R., Larrasa, J., Ambrose, N.C., Parra, A., Alonso, J.M., Hermoso-de-Mendoza, M., Rey, J.M., Hermoso-de-Mendoza, J. Vet. Microbiol. (2004) [Pubmed]
  9. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. Xu, R., Jin, J., Hu, W., Sun, W., Bielawski, J., Szulc, Z., Taha, T., Obeid, L.M., Mao, C. FASEB J. (2006) [Pubmed]
  10. Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts. Sutrina, S.L., Chen, W.W. J. Biol. Chem. (1982) [Pubmed]
  11. Cerebral blood flow velocity patterns during cardiac surgery utilizing profound hypothermia with low-flow cardiopulmonary bypass or circulatory arrest in neonates and infants. Burrows, F.A., Bissonnette, B. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1993) [Pubmed]
 
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